Pyrrole is widely known as a biologically active scaffold which possesses a diverse nature of
activities. The combination of different pharmacophores in a pyrrole ring system has led to …

An overview of pyrroles as distinct scaffolds with therapeutic potential and the significance of
pyrrole derivatives for drug development are provided in this article. It lists instances of …

This report describes a number of substructural features which can help to identify
compounds that appear as frequent hitters (promiscuous compounds) in many biochemical …

We recently reported that shikonin and its analogs were a class of necroptotic inducers that
could bypass cancer drug resistance. However, the molecular targets of shikonin are not …

Copper nanoparticles have been explored as a new class of heterogeneous catalyst in
various chemical transformations. This review surveys the most useful organic …

Antiretroviral therapies (ARTs) have revolutionized the management of human
immunodeficiency virus (HIV) infection, significantly improved patient outcomes, and …

HIV-1 (human immunodeficiency virus type 1) infection begins with the attachment of the
virion to a host cell by its envelope glycoprotein (Env), which subsequently induces fusion of …

The emerging and re-emerging viral infections are constant threats to human health and
wellbeing. Several strategies have been explored to develop vaccines against these viral …

Tetra-and pentasubstituted polyfunctional dihydropyrroles have been concisely synthesized
in high yields by two different processes of the one-pot multicomponent reactions (MCRs) of …

The envelope glycoprotein complex (Env) is responsible for entry of the human
immunodeficiency virus type 1 (HIV-1) into cells by mediating attachment to target cells and …