Gut microbiota in human metabolic health and disease

Y Fan, O Pedersen - Nature Reviews Microbiology, 2021 - nature.com
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …

Gut microbiome composition in obese and non-obese persons: a systematic review and meta-analysis

M Pinart, A Dötsch, K Schlicht, M Laudes, J Bouwman… - Nutrients, 2021 - mdpi.com
Whether the gut microbiome in obesity is characterized by lower diversity and altered
composition at the phylum or genus level may be more accurately investigated using high …

[HTML][HTML] The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice

Y Fan, RK Støving, S Berreira Ibraim… - Nature …, 2023 - nature.com
Anorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are
women and it has a population prevalence of about 1%, but evidence-based treatment is …

Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer

JX Han, ZH Tao, JL Wang, L Zhang, CY Yu… - Nature …, 2023 - nature.com
Epidemiological studies have indicated an association between statin use and reduced
incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a …

Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota

AE Lindell, M Zimmermann-Kogadeeva… - Nature Reviews …, 2022 - nature.com
The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …

Combinatorial, additive and dose-dependent drug–microbiome associations

SK Forslund, R Chakaroun… - Nature, 2021 - nature.com
During the transition from a healthy state to cardiometabolic disease, patients become
heavily medicated, which leads to an increasingly aberrant gut microbiome and serum …

Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease

F Violi, V Cammisotto, S Bartimoccia… - Nature reviews …, 2023 - nature.com
Systemic inflammation has been suggested to have a pivotal role in atherothrombosis, but
the factors that trigger systemic inflammation have not been fully elucidated …

The healthy microbiome—what is the definition of a healthy gut microbiome?

F Shanahan, TS Ghosh, PW O'Toole - Gastroenterology, 2021 - Elsevier
Use of microbiome-based biomarkers in diagnosis, prognosis, risk profiling, and precision
therapy requires definition of a healthy microbiome in different populations. To determine …

Metabolism and metabolic disorders and the microbiome: the intestinal microbiota associated with obesity, lipid metabolism, and metabolic health—pathophysiology …

J Aron-Wisnewsky, MV Warmbrunn, M Nieuwdorp… - Gastroenterology, 2021 - Elsevier
Changes in the intestinal microbiome have been associated with obesity and type 2
diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free …

Temporal variability in quantitative human gut microbiome profiles and implications for clinical research

D Vandeputte, L De Commer, RY Tito… - Nature …, 2021 - nature.com
While clinical gut microbiota research is ever-expanding, extending reference knowledge of
healthy between-and within-subject gut microbiota variation and its drivers remains …