Triplex DNA structures
A DNA triplex is formed when pyrimidine or purine bases occupy the major groove of the
DNA double Helix forming Hoogsteen pairs with purines of the Watson-Crick basepairs …
DNA double Helix forming Hoogsteen pairs with purines of the Watson-Crick basepairs …
Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future
A Ray, B Nordén - The FASEB Journal, 2000 - Wiley Online Library
Synthetic molecules that can bind with high sequence specificity to a chosen target in a
gene sequence are of major interest in medicinal and biotechnological contexts. They show …
gene sequence are of major interest in medicinal and biotechnological contexts. They show …
Stability of peptide nucleic acids in human serum and cellular extracts
VV Demidov, VN Potaman… - Biochemical …, 1994 - Elsevier
The stability of a new type of DNA mimic, peptide nucleic acid (PNA) in human blood serum,
Eschericia coli and Micrococcus luteus extracts and nuclear and cytoplasmic extracts from …
Eschericia coli and Micrococcus luteus extracts and nuclear and cytoplasmic extracts from …
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and
RNA strands more strongly than a corresponding DNA strand, and exhibit increased …
RNA strands more strongly than a corresponding DNA strand, and exhibit increased …
Peptide nucleic acids having amino acid side chains
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and
RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit …
RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit …
Kinetics for hybridization of peptide nucleic acids (PNA) with DNA and RNA studied with the BIAcore technique
The binding of a mixed-sequence pentadecamer PNA (peptide nucleic acid) containing all
four nucleobases to the fully complementary as well as various singly mismatched RNA and …
four nucleobases to the fully complementary as well as various singly mismatched RNA and …
PNA: synthetic polyamide nucleic acids with unusual binding properties
E Uhlmann, A Peyman, G Breipohl… - Angewandte Chemie …, 1998 - Wiley Online Library
The astonishing discovery that peptide nucleic acids (PNAs, B= nucleobase), in spite of their
drastic structural difference to natural DNA, are better nucleic acid mimetics than many other …
drastic structural difference to natural DNA, are better nucleic acid mimetics than many other …
based analytical devices for virus detection: Recent strategies for current and future pandemics
The importance of user-friendly, inexpensive, sensitive, and selective detection of viruses
has been highlighted again due to the recent Coronavirus disease 2019 (COVID-19) …
has been highlighted again due to the recent Coronavirus disease 2019 (COVID-19) …
Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone
During the last decade major efforts have been made to develop synthetic reagents that bind
sequence specifically (or selectively) to double stranded DNA thereby in principle being …
sequence specifically (or selectively) to double stranded DNA thereby in principle being …
Antisense oligonucleotides
A De Mesmaeker, R Haener, P Martin… - Accounts of Chemical …, 1995 - ACS Publications
Until a few decades ago, molecules that exert a therapeutic effect on the human body were
exclusively discovered byserendipity. As our understanding of molecular biology is …
exclusively discovered byserendipity. As our understanding of molecular biology is …