Salinomycin as a potent anticancer stem cell agent: State of the art and future directions

D Qi, Y Liu, J Li, JH Huang, X Hu… - Medicinal research …, 2022 - Wiley Online Library
Cancer stem cells (CSCs) are a small subpopulation of cells within a tumor that can both self‐
renew and differentiate into other cell types forming the heterogeneous tumor bulk. Since …

Salinomycin-based drug delivery systems: overcoming the hurdles in cancer therapy

LR Tefas, C Barbălată, C Tefas, I Tomuță - Pharmaceutics, 2021 - mdpi.com
Cancer stem cells (CSCs) are reportedly responsible for the initiation and propagation of
cancer. Since CSCs are highly resistant to conventional chemo-and radiotherapy, they are …

Lipid nanocapsules co-encapsulating paclitaxel and salinomycin for eradicating breast cancer and cancer stem cells

SM Basu, SK Yadava, R Singh, J Giri - Colloids and Surfaces B …, 2021 - Elsevier
Cancer stem cells (CSCs) comprise a diminutive population of the tumor but pose major
obstacles in cancer treatment, often their presence being correlated with poor prognosis …

A peptide-salinomycin conjugate with a bystander effect reduces the stemness characteristics of ovarian cancer cells and enhances drug sensitivity

C Hao, P Chen, S Setrerrahmane, H Xu - European Journal of Medicinal …, 2024 - Elsevier
Salinomycin (Sal) has attracted considerable attention in the field of tumor treatment,
especially for its inhibitory effect on cancer stem cells (CSCs) and drug-resistant tumor cells …

[HTML][HTML] Salinomycin-loaded high-density lipoprotein exerts promising anti-ovarian cancer effects by inhibiting epithelial–mesenchymal transition

M Zou, X Yin, X Zhou, X Niu, Y Wang… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Background Effective treatments for ovarian cancer remain elusive, and survival rates have
long been considered grim. Ovarian cancer stem cells (OCSCs) and epithelial …

Salinomycin and IR780-loaded upconversion nanoparticles influence biological behavior of liver cancer stem cells by persistently activating the MAPK signaling …

B Zhang, Z Ding, X Wen, G Song, Q Luo - Experimental Cell Research, 2024 - Elsevier
The combination of chemotherapy and phototherapy has emerged as a promising
therapeutic approach for enhancing the efficacy of cancer treatment and mitigating drug …

[PDF][PDF] QUALITY BY DESIGN APPROACH FOR THE DEVELOPMENT OF SALINOMYCIN AND GEMCITABINE COMBINATION THERAPY LIPOSOMES FOR …

LR Tefas, I Toma, I TOMUȚĂ - Farmacia, 2022 - farmaciajournal.com
An ideal cancer treatment would eradicate all types of malignant cells, both rapidly
replicating and quiescent stem-like cancer cells. Therefore, a combination of drugs capable …

Salinomycin attenuates kidney fibrosis and inflammation in mice with unilateral ureteral obstruction

KH Chen, HH Hsu, HY Yang, YC Ko… - … and Biophysical Research …, 2025 - Elsevier
Renal fibrosis is a crucial pathological feature in chronic kidney disease (CKD), resulting in
the gradual decline of renal function. Salinomycin is an antibiotic discovered from …

LC–MS/MS analysis of coccidiostats in meat supply chain safety

C Ancillotti, L Bonciani, D Passerini… - Journal of Mass …, 2024 - Wiley Online Library
The presence of coccidiostats in meat products represents an important topic because of the
animal administration of these substances, authorized as feed additives for targeted species …