Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

KD Davis, N Aghaeepour, AH Ahn, MS Angst… - Nature Reviews …, 2020 - nature.com
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

Building better biomarkers: brain models in translational neuroimaging

CW Woo, LJ Chang, MA Lindquist, TD Wager - Nature neuroscience, 2017 - nature.com
Despite its great promise, neuroimaging has yet to substantially impact clinical practice and
public health. However, a develo** synergy between emerging analysis techniques and …

Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations

KD Davis, H Flor, HT Greely, GD Iannetti… - Nature Reviews …, 2017 - nature.com
Chronic pain is the greatest source of disability globally and claims related to chronic pain
feature in many insurance and medico-legal cases. Brain imaging (for example, functional …

Somatic and vicarious pain are represented by dissociable multivariate brain patterns

A Krishnan, CW Woo, LJ Chang, L Ruzic, X Gu… - elife, 2016 - elifesciences.org
Understanding how humans represent others' pain is critical for understanding pro-social
behavior.'Shared experience'theories propose common brain representations for somatic …

Placebo effects on the neurologic pain signature: a meta-analysis of individual participant functional magnetic resonance imaging data

M Zunhammer, U Bingel, TD Wager… - JAMA …, 2018 - jamanetwork.com
Importance Placebo effects reduce pain and contribute to clinical analgesia, but after
decades of research, it remains unclear whether placebo treatments mainly affect …

Neuroimaging-based biomarkers for pain: state of the field and current directions

MM Van Der Miesen, MA Lindquist, TD Wager - Pain reports, 2019 - journals.lww.com
Chronic pain is an endemic problem involving both peripheral and brain pathophysiology.
Although biomarkers have revolutionized many areas of medicine, biomarkers for pain have …

Progress and roadblocks in the search for brain-based biomarkers of autism and attention-deficit/hyperactivity disorder

LQ Uddin, DR Dajani, W Voorhies, H Bednarz… - Translational …, 2017 - nature.com
Children with neurodevelopmental disorders benefit most from early interventions and
treatments. The development and validation of brain-based biomarkers to aid in objective …

Brain imaging biomarkers for chronic pain

Z Zhang, JS Gewandter, P Geha - Frontiers in Neurology, 2022 - frontiersin.org
The prevalence of chronic pain has reached epidemic levels. In addition to personal
suffering chronic pain is associated with psychiatric and medical co-morbidities, notably …

Compromised hippocampus‐striatum pathway as a potential imaging biomarker of mild‐traumatic brain injury and posttraumatic stress disorder

D Rangaprakash, G Deshpande, TA Daniel… - Human brain …, 2017 - Wiley Online Library
Objectives Military service members risk acquiring posttraumatic stress disorder (PTSD) and
mild‐traumatic brain injury (mTBI), with high comorbidity. Owing to overlap** …

Neuroimaging-based pain biomarkers: definitions, clinical and research applications, and evaluation frameworks to achieve personalized pain medicine

S Mackey, HT Greely, KT Martucci - Pain reports, 2019 - journals.lww.com
One of the key ambitions of neuroimaging-based pain biomarker research is to augment
patient and clinician reporting of clinically relevant phenomena with neural measures for …