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Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
Building better biomarkers: brain models in translational neuroimaging
Despite its great promise, neuroimaging has yet to substantially impact clinical practice and
public health. However, a develo** synergy between emerging analysis techniques and …
public health. However, a develo** synergy between emerging analysis techniques and …
Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations
Chronic pain is the greatest source of disability globally and claims related to chronic pain
feature in many insurance and medico-legal cases. Brain imaging (for example, functional …
feature in many insurance and medico-legal cases. Brain imaging (for example, functional …
Somatic and vicarious pain are represented by dissociable multivariate brain patterns
Understanding how humans represent others' pain is critical for understanding pro-social
behavior.'Shared experience'theories propose common brain representations for somatic …
behavior.'Shared experience'theories propose common brain representations for somatic …
Placebo effects on the neurologic pain signature: a meta-analysis of individual participant functional magnetic resonance imaging data
Importance Placebo effects reduce pain and contribute to clinical analgesia, but after
decades of research, it remains unclear whether placebo treatments mainly affect …
decades of research, it remains unclear whether placebo treatments mainly affect …
Neuroimaging-based biomarkers for pain: state of the field and current directions
Chronic pain is an endemic problem involving both peripheral and brain pathophysiology.
Although biomarkers have revolutionized many areas of medicine, biomarkers for pain have …
Although biomarkers have revolutionized many areas of medicine, biomarkers for pain have …
Progress and roadblocks in the search for brain-based biomarkers of autism and attention-deficit/hyperactivity disorder
Children with neurodevelopmental disorders benefit most from early interventions and
treatments. The development and validation of brain-based biomarkers to aid in objective …
treatments. The development and validation of brain-based biomarkers to aid in objective …
Brain imaging biomarkers for chronic pain
The prevalence of chronic pain has reached epidemic levels. In addition to personal
suffering chronic pain is associated with psychiatric and medical co-morbidities, notably …
suffering chronic pain is associated with psychiatric and medical co-morbidities, notably …
Compromised hippocampus‐striatum pathway as a potential imaging biomarker of mild‐traumatic brain injury and posttraumatic stress disorder
Objectives Military service members risk acquiring posttraumatic stress disorder (PTSD) and
mild‐traumatic brain injury (mTBI), with high comorbidity. Owing to overlap** …
mild‐traumatic brain injury (mTBI), with high comorbidity. Owing to overlap** …
Neuroimaging-based pain biomarkers: definitions, clinical and research applications, and evaluation frameworks to achieve personalized pain medicine
One of the key ambitions of neuroimaging-based pain biomarker research is to augment
patient and clinician reporting of clinically relevant phenomena with neural measures for …
patient and clinician reporting of clinically relevant phenomena with neural measures for …