Consequences of adolescent drug use

MR Steinfeld, MM Torregrossa - Translational psychiatry, 2023 - nature.com
Substance use in adolescence is a known risk factor for the development of neuropsychiatric
and substance use disorders in adulthood. This is in part due to the fact that critical aspects …

Women are taking the hit: examining the unique consequences of cannabis use across the female lifespan

EL Gräfe, HMO Reid, I Shkolnikov, K Conway… - Frontiers in …, 2023 - Elsevier
Cannabis use has risen dramatically in recent years due to global decriminalization and a
resurgence in the interest of potential therapeutic benefits. While emerging research is …

Metabotropic NMDAR Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory

AA Le, JC Lauterborn, Y Jia, CD Cox, G Lynch… - Journal of …, 2024 - jneurosci.org
NMDA receptor (NMDAR)-mediated calcium influx triggers the induction and initial
expression of long-term potentiation (LTP). Here we report that in male rodents, ion flux …

The effect of traumatic brain injury on learning and memory: A synaptic focus

E Eyolfson, KRB Suesser, H Henry… - The …, 2024 - journals.sagepub.com
Deficits in learning and memory are some of the most commonly reported symptoms
following a traumatic brain injury (TBI). We will examine whether the neural basis of these …

Neural basis of adolescent THC-induced potentiation of opioid responses later in life

E Hubbard, P Derdeyn, VM Galinato, A Wu… - …, 2024 - nature.com
Use of one addictive drug typically influences the behavioral response to other drugs, either
administered at the same time or a subsequent time point. The nature of the drugs being …

Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats

MX Martinez, V Alizo Vera, CM Ruiz, SB Floresco… - …, 2024 - Springer
Rationale Adolescent cannabis use is linked to later-life changes in cognition, learning, and
memory. Rodent experimental studies suggest Δ9-tetrahydrocannabinol (THC) influences …

Sex differences in the context dependency of episodic memory

AA Le, LC Palmer, J Chavez, CM Gall… - Frontiers in Behavioral …, 2024 - frontiersin.org
Context contributes to multiple aspects of human episodic memory including segmentation
and retrieval. The present studies tested if, in adult male and female mice, context influences …

Pre-versus post-synaptic forms of LTP in two branches of the same hippocampal afferent

J Quintanilla, Y Jia, BS Pruess, J Chavez… - Journal of …, 2024 - jneurosci.org
There has been considerable controversy about pre-versus postsynaptic expression of
memory-related long-term potentiation (LTP), with corresponding disputes about underlying …

Postnatal GABAA Receptor Activation Alters Synaptic Plasticity and Cognition in Adult Wistar Rats

M Amani, F Mohammadian, N Golitabari… - Molecular …, 2022 - Springer
Early life alteration in the activity of gamma-aminobutyric acid (GABA) receptors is
associated with long-lasting developmental effects on the brain and behavior. GABAA …

Metabotropic NMDA Receptor Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory

AA Le, JC Lauterborn, Y Jia, CD Cox, G Lynch… - …, 2024 - pmc.ncbi.nlm.nih.gov
Men generally outperform women on encoding spatial components of episodic memory
whereas the reverse holds for semantic elements. Here we show that female mice …