Cellular mechanisms mediating exercise-induced protection against cardiotoxic anthracycline cancer therapy

S Dozic, EJ Howden, JR Bell, KM Mellor… - Cells, 2023 - mdpi.com
Anthracyclines such as doxorubicin are widely used chemotherapy drugs. A common side
effect of anthracycline therapy is cardiotoxicity, which can compromise heart function and …

The efficacy and safety of exercise regimens to mitigate chemotherapy cardiotoxicity: a systematic review and meta-analysis of randomized controlled trials

AM Amin, Y Khlidj, M Abuelazm, AA Ibrahim… - Cardio-Oncology, 2024 - Springer
Background Cardiotoxicity is one of the most common adverse events of the chemotherapy.
Physical exercise was shown to be cardioprotective. We aim to estimate the efficacy and …

[HTML][HTML] Chemotherapy-induced myopathy: the dark side of the cachexia sphere

DG Campelj, CA Goodman, E Rybalka - Cancers, 2021 - mdpi.com
Simple Summary In addition to cancer-related factors, anti-cancer chemotherapy treatment
can drive life-threatening body wasting in a syndrome known as cachexia. Emerging …

Targeting mitochondrial dynamics proteins for the treatment of doxorubicin-induced cardiotoxicity

R Chen, M Niu, X Hu, Y He - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
Doxorubicin (DOX) is an extensively used chemotherapeutic agent that can cause severe
and frequent cardiotoxicity, which limits its clinical application. Although there have been …

Quercetin improved muscle mass and mitochondrial content in a murine model of cancer and chemotherapy-induced cachexia

BN VanderVeen, TD Cardaci, P Cunningham… - Nutrients, 2022 - mdpi.com
A cachexia diagnosis is associated with a doubling in hospital stay and increased
healthcare cost for cancer patients and most cachectic patients do not survive treatment …

Scutellarin attenuates doxorubicin‐induced cardiotoxicity by inhibiting myocardial fibrosis, apoptosis and autophagy in rats

X Sun, L Zhou, Y Han, Q Yang, X Li, B **n… - Chemistry & …, 2023 - Wiley Online Library
The anthracycline antibiotic doxorubicin (DOX) is an effective anticancer agent, but its
clinical use is limited by dose‐dependent cardiotoxicity. Scutellarin (SCU), a natural …

Doxorubicin-induced oxidative stress differentially regulates proteolytic signaling in cardiac and skeletal muscle

RN Montalvo, V Doerr, K Min… - American Journal of …, 2020 - journals.physiology.org
Doxorubicin (DOX) is a highly effective antineoplastic agent used in cancer treatment.
Unfortunately, clinical use of DOX is limited due to the development of dose-dependent …

Targeting mitochondria and oxidative stress in cancer-and chemotherapy-induced muscle wasting

JR Huot, D Baumfalk, A Resendiz… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Cancer is frequently associated with the early appearance of cachexia, a
multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a …

Effects of exercise preconditioning on doxorubicin-induced liver and kidney toxicity in male and female rats

FP Boeno, J Patel, RN Montalvo… - International Journal of …, 2023 - mdpi.com
Doxorubicin (DOX) is a highly effective chemotherapy agent prescribed for cancer treatment.
However, the clinical use of DOX is limited due to off-target toxicity in healthy tissues. In this …

Exercise stimulates beneficial adaptations to diminish doxorubicin-induced cellular toxicity

AJ Smuder - American Journal of Physiology-Regulatory …, 2019 - journals.physiology.org
Doxorubicin (DOX) is a highly effective antitumor agent used for the treatment of a wide
range of cancers. Unfortunately, DOX treatment results in cytotoxic side effects due to its …