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Cellular mechanisms mediating exercise-induced protection against cardiotoxic anthracycline cancer therapy
Anthracyclines such as doxorubicin are widely used chemotherapy drugs. A common side
effect of anthracycline therapy is cardiotoxicity, which can compromise heart function and …
effect of anthracycline therapy is cardiotoxicity, which can compromise heart function and …
The efficacy and safety of exercise regimens to mitigate chemotherapy cardiotoxicity: a systematic review and meta-analysis of randomized controlled trials
Background Cardiotoxicity is one of the most common adverse events of the chemotherapy.
Physical exercise was shown to be cardioprotective. We aim to estimate the efficacy and …
Physical exercise was shown to be cardioprotective. We aim to estimate the efficacy and …
[HTML][HTML] Chemotherapy-induced myopathy: the dark side of the cachexia sphere
Simple Summary In addition to cancer-related factors, anti-cancer chemotherapy treatment
can drive life-threatening body wasting in a syndrome known as cachexia. Emerging …
can drive life-threatening body wasting in a syndrome known as cachexia. Emerging …
Targeting mitochondrial dynamics proteins for the treatment of doxorubicin-induced cardiotoxicity
R Chen, M Niu, X Hu, Y He - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
Doxorubicin (DOX) is an extensively used chemotherapeutic agent that can cause severe
and frequent cardiotoxicity, which limits its clinical application. Although there have been …
and frequent cardiotoxicity, which limits its clinical application. Although there have been …
Quercetin improved muscle mass and mitochondrial content in a murine model of cancer and chemotherapy-induced cachexia
A cachexia diagnosis is associated with a doubling in hospital stay and increased
healthcare cost for cancer patients and most cachectic patients do not survive treatment …
healthcare cost for cancer patients and most cachectic patients do not survive treatment …
Scutellarin attenuates doxorubicin‐induced cardiotoxicity by inhibiting myocardial fibrosis, apoptosis and autophagy in rats
X Sun, L Zhou, Y Han, Q Yang, X Li, B **n… - Chemistry & …, 2023 - Wiley Online Library
The anthracycline antibiotic doxorubicin (DOX) is an effective anticancer agent, but its
clinical use is limited by dose‐dependent cardiotoxicity. Scutellarin (SCU), a natural …
clinical use is limited by dose‐dependent cardiotoxicity. Scutellarin (SCU), a natural …
Doxorubicin-induced oxidative stress differentially regulates proteolytic signaling in cardiac and skeletal muscle
Doxorubicin (DOX) is a highly effective antineoplastic agent used in cancer treatment.
Unfortunately, clinical use of DOX is limited due to the development of dose-dependent …
Unfortunately, clinical use of DOX is limited due to the development of dose-dependent …
Targeting mitochondria and oxidative stress in cancer-and chemotherapy-induced muscle wasting
Significance: Cancer is frequently associated with the early appearance of cachexia, a
multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a …
multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a …
Effects of exercise preconditioning on doxorubicin-induced liver and kidney toxicity in male and female rats
Doxorubicin (DOX) is a highly effective chemotherapy agent prescribed for cancer treatment.
However, the clinical use of DOX is limited due to off-target toxicity in healthy tissues. In this …
However, the clinical use of DOX is limited due to off-target toxicity in healthy tissues. In this …
Exercise stimulates beneficial adaptations to diminish doxorubicin-induced cellular toxicity
AJ Smuder - American Journal of Physiology-Regulatory …, 2019 - journals.physiology.org
Doxorubicin (DOX) is a highly effective antitumor agent used for the treatment of a wide
range of cancers. Unfortunately, DOX treatment results in cytotoxic side effects due to its …
range of cancers. Unfortunately, DOX treatment results in cytotoxic side effects due to its …