Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …

The renin‐angiotensin system (RAS) plays essential roles in maintaining peripheral
cardiovascular homeostasis, with its potential roles in the brain only being recognized more …

The neuromodulators dopamine (DA) and serotonin (5-hydroxytryptamine; 5HT) powerfully
regulate associative learning1–8. Similarities in the activity and connectivity of these …

MDMA (3, 4-methylenedioxymethamphetamine) is a psychoactive drug with powerful
prosocial effects. While MDMA is sometimes termed an “empathogen,” empirical studies …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Opioid use disorder (OUD) is a chronic brain disease which originates from long-term
neuroadaptations that develop after repeated opioid consumption and withdrawal episodes …

The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been
implicated in a wide range of behaviors and emotional states. Emerging evidence, primarily …

Abstract Alcohol Use Disorder (AUD) is a leading cause of death and disability worldwide,
but current treatments are insufficient in fully addressing the symptoms that often lead to …

There is a lack of understanding of the neural mechanisms regulating the rewarding effects
of social interactions. A significant contributor to this lack of clarity is the diversity of social …

Opioid addiction is characterized by adaptations in the mesolimbic dopamine system that
occur during chronic opioid use. Alterations in dopaminergic transmission contribute to …