Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling
molecules in many organs, including the brain and endocrine systems. There has been …

Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …

Background Recent clinical and experimental studies have highlighted the involvement of
Ventral Tegmental Area (VTA) dopamine (DA) neurons for the early pathogenesis of …

Abstract d-Serine acts as a co-agonist of N-methyl-d-aspartate receptors (NMDAR) which
appear overactivated in AD, while d-aspartate is a modulatory molecule acting on NMDAR …

L-serine generated in astrocytes plays a pivotal role in modulating essential neurometabolic
processes, while its enantiomer, D-serine, specifically regulates NMDA receptor (NMDAR) …

Treatment-resistant schizophrenia (TRS) or suboptimal response to antipsychotics affects
almost 30% of schizophrenia (SCZ) patients, and it is a relevant clinical issue with significant …

The endogenous NMDA receptor (NMDAR) agonist d-aspartate occurs transiently in the
mammalian brain because it is abundant during embryonic and perinatal phases before …

The endogenous amino acids serine and aspartate occur at high concentrations in free D-
form in mammalian organs, including the central nervous system and endocrine glands. D …

The D-aspartate oxidase (DDO) gene encodes the enzyme responsible for the catabolism of
D-aspartate, an atypical amino acid enriched in the mammalian brain and acting as an …

It is long acknowledged that the N-methyl d-aspartate receptor co-agonist, d-serine, plays a
crucial role in several N-methyl d-aspartate receptor-mediated physiological and …