Unlike other steroid hormone receptors, the glucocorticoid receptor (GR) is not considered
an oncogene. In breast cancer, the estrogen receptor (ER) drives cell growth, proliferation …

First described for their metabolic and immunosuppressive effects, glucocorticoids are
widely prescribed in clinical settings of inflammation. However, glucocorticoids are also …

Summary ZUMA‐1 (NCT02348216) examined the safety and efficacy of axicabtagene
ciloleucel (axi‐cel), an autologous CD19‐directed chimaeric antigen receptor (CAR)‐T cell …

Controlling the balance between immunity and immunopathology is crucial for host
resistance to pathogens. After infection, activation of the hypothalamic–pituitary–adrenal …

Rationale: Stratification of asthma at the molecular level, especially using accessible
biospecimens, could greatly enable patient selection for targeted therapy. Objectives: To …

Corticosteroids have been used for decades to modulate inflammation therapeutically, yet
there is a paucity of data on their effects in humans. We examined the changes in cellular …

While outcomes for children with T-cell acute lymphoblastic leukemia (T-ALL) have
improved dramatically, survival rates for patients with relapsed/refractory disease remain …

Numerous p53 target genes have been implicated in DNA damage–induced apoptosis
signaling, but proapoptotic Bcl-2 (B-cell leukemia 2) family members of the BH3 (Bcl-2 …

Glioblastoma multiforme (GBM) is a highly malignant primary brain cancer with a dreadful
overall survival and for which treatment options are limited. Recent breakthroughs in novel …

Glucocorticoids (GCs) have been widely used for decades as a first-line treatment for
inflammatory and autoimmune diseases. However, their use is often hampered by the onset …