Candida albicans is a multimorphic commensal organism and opportunistic fungal pathogen
in humans. A morphological switch between unicellular budding yeast and multicellular …

Over-expression of the human P-glycoprotein (P-gp) in tumor cells is a classic example of an
ABC protein serving as a hindrance to effective chemotherapy. The existence of proteins …

Candida albicans is a commensal yeast of most healthy individuals, but also one of the most
prevalent human fungal pathogens. During adaptation to the mammalian host, C. albicans …

Drug resistance mechanisms in the commensal human pathogen Candida albicans are
continually evolving. Over time, Candida species have implemented diverse strategies to …

The deleterious effects of human-induced climate change have long been predicted.
However, the imminent emergence and spread of new diseases, including fungal infections …

The capacity to respond to temperature fluctuations is critical for microorganisms to survive
within mammalian hosts, and temperature modulates virulence traits of diverse pathogens …

Aims This study aimed to investigate whether berberine (BBR) can inhibit the iron reduction
mechanism of Candida albicans, lowering the iron uptake of the yeast and perhaps having …

The impact of fungal pathogens on human health is devastating. For fungi and other
pathogens, a key determinant of virulence is the capacity to thrive at host temperatures, with …

Background Metal-responsive transcription factor 1 (MTF-1) induces the expression of
metallothioneins (MTs) which bind and sequester labile metal ions. While MTF-1 primarily …

Morphological plasticity is a key virulence trait for many fungal pathogens. For the
opportunistic fungal pathogen Candida albicans, transitions among yeast, pseudohyphal …