Berberine as a potential anticancer agent: A comprehensive review

A Rauf, T Abu-Izneid, AA Khalil, M Imran, ZA Shah… - Molecules, 2021 - mdpi.com
Berberine (BBR), a potential bioactive agent, has remarkable health benefits. A substantial
amount of research has been conducted to date to establish the anticancer potential of BBR …

Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine

S Singh, N Pathak, E Fatima, AS Negi - European journal of medicinal …, 2021 - Elsevier
Alkaloids are one of the most important classes of plant bioactives. Among these
isoquinoline alkaloids possess varied structures and exhibit numerous biological activities …

The metabolism of berberine and its contribution to the pharmacological effects

K Wang, X Feng, L Chai, S Cao, F Qiu - Drug metabolism reviews, 2017 - Taylor & Francis
Berberine, a bioactive alkaloid isolated from several herbal substances, possesses multiple
pharmacological effects, including antimicrobial, antidiabetic, anticancer activities …

The biological activity of natural alkaloids against herbivores, cancerous cells and pathogens

A Thawabteh, S Juma, M Bader, D Karaman, L Scrano… - Toxins, 2019 - mdpi.com
The growing incidence of microorganisms that resist antimicrobials is a constant concern for
the scientific community, while the development of new antimicrobials from new chemical …

Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system

K Zou, Z Li, Y Zhang, H Zhang, B Li, W Zhu… - Acta Pharmacologica …, 2017 - nature.com
It has been widely recognized that inflammation, particularly chronic inflammation, can
increase the risk of cancer and that the simultaneous treatment of inflammation and cancer …

Recent advances in phytochemical based nano-drug delivery systems to combat breast cancer: A review

R Solanki, B Jodha, KE Prabina, N Aggarwal… - Journal of Drug Delivery …, 2022 - Elsevier
Breast Cancer is the most common cancer in women worldwide. Recently bioactive plant
products, namely phytochemicals are being been explored by researchers for their …

Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis

H Gali-Muhtasib, R Hmadi, M Kareh, R Tohme… - Apoptosis, 2015 - Springer
Despite remarkable progress in the discovery and development of novel cancer
therapeutics, cancer remains the second leading cause of death in the world. For many …

Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer–A comprehensive review from chemotherapy to immunotherapy

PJ Kaboli, F Salimian, S Aghapour, S **ang… - Pharmacological …, 2020 - Elsevier
Breast cancer is the most frequently occurring cancer in women. Chemotherapy in
combination with immunotherapy has been used to treat breast cancer. Atezolizumab …

[HTML][HTML] m1A regulated genes modulate PI3K/AKT/mTOR and ErbB pathways in gastrointestinal cancer

Y Zhao, Q Zhao, PJ Kaboli, J Shen, M Li, X Wu… - Translational …, 2019 - Elsevier
BACKGROUND: Gene expression can be posttranscriptionally regulated by a complex
network of proteins. N1-methyladenosine (m1A) is a newly validated RNA modification …

In silico polypharmacology of natural products

J Fang, C Liu, Q Wang, P Lin… - Briefings in bioinformatics, 2018 - academic.oup.com
Natural products with polypharmacological profiles have demonstrated promise as novel
therapeutics for various complex diseases, including cancer. Currently, many gaps exist in …