C2H2 (Cys-Cys-His-His motif) zinc finger proteins are members of a large superfamily of
nucleic-acid-binding proteins in eukaryotes. On the basis of NMR and X-ray structures, we …

CRM1 mediates the nuclear export of proteins exposing leucine-rich nuclear-export signals
(NESs). Most NESs bind to CRM1 with relatively low affinity. Recently, higher-affinity NESs …

In mammalian cells, the nuclear export receptor, Exportin 5 (Exp5), exports pre-microRNAs
(pre-miRNAs) as well as tRNAs into the cytoplasm. In this study, we examined the function of …

The DNA damage response involves a complex network of processes that detect and repair
DNA damage. Here we show that miRNA biogenesis is globally induced upon DNA damage …

Faithful transmission of genetic material in eukaryotic cells requires not only accurate DNA
replication and chromosome distribution but also the ability to sense and repair …

Regulator of chromatin condensation 1 (RCC1) is the only known guanine nucleotide-
exchange factor for the Ran GTPase and has pivotal roles in nucleo-cytoplasmic transport …

Double-stranded RNA (dsRNA)-binding proteins interact with substrate RNAs via dsRNA-
binding domains (dsRBDs). Several proteins harboring these domains exhibit …

The post-translational methylation of α-amino groups was first discovered over 30 years ago
on the bacterial ribosomal proteins L16 and L33 (refs,), but almost nothing is known about …

Background MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs
(ncRNAs) which play important roles in eukaryotic gene regulation. miRNA biogenesis and …

MicroRNAs (miRNAs) are a class of small, noncoding RNAs that function by regulating gene
expression post-transcriptionally. Alterations in miRNA expression can strongly influence …