Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

INTRODUCTION Dendritic cells (DCs) and monocytes consist of multiple specialized
subtypes that play a central role in pathogen sensing, phagocytosis, and antigen …

Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Carbohydrates are the most abundant and one of the most important biomacromolecules in
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …

Studies in mice and humans have revealed intriguing associations between host genetics
and the microbiome. Here we report a 16S rRNA-based analysis of the gut microbiome in …

Currently approved immune checkpoint inhibitor therapies targeting the PD-1 and CTLA-4
receptor pathways are powerful treatment options for certain cancers; however, most …

Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading
causes of death and among the most costly medical conditions in the Western world. In all …

Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …