Decoding the brain: From neural representations to mechanistic models

MW Mathis, AP Rotondo, EF Chang, AS Tolias… - Cell, 2024 - cell.com
A central principle in neuroscience is that neurons within the brain act in concert to produce
perception, cognition, and adaptive behavior. Neurons are organized into specialized brain …

Sourcerer: Sample-based maximum entropy source distribution estimation

J Vetter, G Moss, C Schröder, R Gao… - arxiv preprint arxiv …, 2024 - arxiv.org
Scientific modeling applications often require estimating a distribution of parameters
consistent with a dataset of observations-an inference task also known as source distribution …

[HTML][HTML] Controlling morpho-electrophysiological variability of neurons with detailed biophysical models

A Arnaudon, M Reva, M Zbili, H Markram, W Van Geit… - Iscience, 2023 - cell.com
Variability, which is known to be a universal feature among biological units such as neuronal
cells, holds significant importance, as, for example, it enables a robust encoding of a high …

Transcriptomic correlates of state modulation in GABAergic interneurons: A cross-species analysis

J Keijser, L Hertäg, H Sprekeler - Journal of Neuroscience, 2024 - jneurosci.org
GABAergic inhibitory interneurons comprise many subtypes that differ in their molecular,
anatomical, and functional properties. In mouse visual cortex, they also differ in their …

Higher-Order Interactions in Neuronal Function: From Genes to Ionic Currents in Biophysical Models

M Reva, A Arnaudon, M Zbili, H Markram, JM Goaillard… - bioRxiv, 2024 - biorxiv.org
Neuronal firing patterns are the consequence of precise variations in neuronal membrane
potential, which are themselves shaped by multiple ionic currents. In this study, we use …

[CITATION][C] Investigating model misspecification in simulation-based inference

PL Rodrigues, I Statify, MN Arbel, I Thoth, F Forbes… - 2022