Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

A comprehensive review of published literature was conducted to elucidate the genetics,
neuropathology, imaging findings, prevalence, clinical course, diagnosis/clinical evaluation …

Introduction: Leukodystrophies constitute heterogenous group of rare heritable disorders
primarily affecting the white matter of central nervous system. These conditions are often …

Leukodystrophies constitute a large and heterogeneous group of genetic diseases primarily
affecting the white matter of the central nervous system. Different disorders target different …

Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM)
changes on brain MRI, which often trigger biochemical and genetic confirmation of the …

Diffusion‐weighted imaging, a contrast unique to MRI, is used for assessment of tissue
microstructure in vivo. However, this exquisite sensitivity to finer scales far above imaging …

Objectives The leukodystrophy “vanishing white matter”(VWM) and “metachromatic
leukodystrophy”(MLD) affect the brain's white matter, but have very different underlying …

Leukodystrophies are a class of rare inherited central nervous system (CNS) disorders that
affect the white matter of the brain, typically leading to progressive neurodegeneration and …

Leukodystrophies, a group of rare demyelinating disorders, mainly affect the CNS. Clinical
presentation of different types of leukodystrophies can be nonspecific, and thus, imaging …

Enzyme replacement therapy has drastically changed prospects of patients with Pompe
disease, a progressive metabolic myopathy. As classic infantile patients survive due to …