Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Chromone: a valid scaffold in medicinal chemistry
Chromones are a group of naturally occurring compounds that are ubiquitous in nature,
especially in plants. The word chromone is derived from the Greek word chroma, meaning …
especially in plants. The word chromone is derived from the Greek word chroma, meaning …
Chromones as a privileged scaffold in drug discovery: A review
The chromone and its derivatives are the most important heterocyclic compounds, which is a
common and integral feature of a variety of natural products and medicinal agents. These …
common and integral feature of a variety of natural products and medicinal agents. These …
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
ST Sudevan, JM Oh, MA Abdelgawad… - Scientific reports, 2022 - nature.com
The inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease
SS **e, X Wang, N Jiang, W Yu, KDG Wang… - European Journal of …, 2015 - Elsevier
A series of novel tacrine-coumarin hybrids were designed, synthesized and evaluated as
multi-target agents against Alzheimer's disease. The biological assays indicated that most of …
multi-target agents against Alzheimer's disease. The biological assays indicated that most of …
A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease
L Jalili-Baleh, E Babaei, S Abdpour… - European journal of …, 2018 - Elsevier
Abstract Alzheimer's disease (AD), the most common form of dementia, is a multifactorial
neurodegenerative disease. The target enzymes inhibition including cholinesterase, beta …
neurodegenerative disease. The target enzymes inhibition including cholinesterase, beta …
Monoamine oxidase B inhibitors based on natural privileged scaffolds: A review of systematically structural modification
Y Lv, Z Zheng, R Liu, J Guo, C Zhang, Y **e - International Journal of …, 2023 - Elsevier
Monoamine oxidase is a flavin enzyme that catalyzes the oxidation of monoamine
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …
Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation
A series of new coumarin-dithiocarbamate hybrids were designed and synthesized as
multitarget agents for the treatment of Alzheimer's disease. Most of them showed potent and …
multitarget agents for the treatment of Alzheimer's disease. Most of them showed potent and …
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B …
Y Li, X Qiang, L Luo, X Yang, G **ao, Y Zheng… - Bioorganic & Medicinal …, 2017 - Elsevier
A series of homoisoflavonoid Mannich base derivatives were designed, synthesized and
evaluated as multifunctional agents against Alzheimer's disease. It demonstrated that most …
evaluated as multifunctional agents against Alzheimer's disease. It demonstrated that most …
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as
monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to …
monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to …