Tumor angiogenesis and anti-angiogenic strategies for cancer treatment

RI Teleanu, C Chircov, AM Grumezescu… - Journal of clinical …, 2019 - mdpi.com
Angiogenesis is the process through which novel blood vessels are formed from pre-existing
ones and it is involved in both physiological and pathological processes of the body …

The application and research progress of anti-angiogenesis therapy in tumor immunotherapy

J Tu, H Liang, C Li, Y Huang, Z Wang, X Chen… - Frontiers in …, 2023 - frontiersin.org
Tumor immunotherapy, as the focus of scientific research and clinical tumor treatment in
recent years, has received extensive attention. Due to its remarkable curative effect and …

Cardiovascular effects of caffeic acid and its derivatives: a comprehensive review

H Silva, NMF Lopes - Frontiers in physiology, 2020 - frontiersin.org
Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic
acids with an interesting array of biological activities; eg, antioxidant, anti-inflammatory …

Therapeutic angiogenesis-based strategy for peripheral artery disease

J Han, L Luo, O Marcelina, V Kasim, S Wu - Theranostics, 2022 - pmc.ncbi.nlm.nih.gov
Peripheral artery disease (PAD) poses a great challenge to society, with a growing
prevalence in the upcoming years. Patients in the severe stages of PAD are prone to …

[HTML][HTML] Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p

J Lou, J Wu, M Feng, X Dang, G Wu, H Yang… - Journal of Sport and …, 2022 - Elsevier
Background Angiogenesis constitutes a major mechanism responsible for exercise-induced
beneficial effects. Our previous study identified a cluster of differentially expressed …

Mechanoregulation of vascular endothelial growth factor receptor 2 in angiogenesis

B Miller, MK Sewell-Loftin - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
The endothelial cells that compose the vascular system in the body display a wide range of
mechanotransductive behaviors and responses to biomechanical stimuli, which act in …

Insights into the dual role of angiogenesis following stroke

R Rust - Journal of Cerebral Blood Flow & Metabolism, 2020 - journals.sagepub.com
Stroke remains a major cause of serious disability due to the brain's limited capacity to
regenerate. Current treatments focus on acute recanalization of the occluded blood vessels; …

Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression

H Yao, J Li, Z Liu, C Ouyang, Y Qiu, X Zheng, J Mu… - Autophagy, 2023 - Taylor & Francis
Ischemia-induced angiogenesis is critical for blood flow restoration and tissue regeneration,
but the underlying molecular mechanism is not fully understood. ATG7 (autophagy related 7) …

Ischemia induces autophagy of endothelial cells and stimulates angiogenic effects in a hindlimb ischemia mouse model

IH Jeong, WY Bae, JS Choi, JW Jeong - Cell Death & Disease, 2020 - nature.com
Although peripheral artery disease (PAD) is a major health problem, there have been limited
advances in medical therapies. In PAD patients, angiogenesis is regarded as a promising …

[HTML][HTML] Therapeutic potential of endothelial colony-forming cells in ischemic disease: strategies to improve their regenerative efficacy

P Faris, S Negri, A Perna, V Rosti, G Guerra… - International journal of …, 2020 - mdpi.com
Cardiovascular disease (CVD) comprises a range of major clinical cardiac and circulatory
diseases, which produce immense health and economic burdens worldwide. Currently …