DNA damage responses (DDR) encompass DNA repair and signal transduction pathways
that effect cell cycle checkpoint arrest and/or apoptosis. How DDR pathways respond to low …

There is a large increase in lymphoid malignancy in AT patients and a total absence of
myeloid tumors. Penetrance of the tumor phenotype is about 10% to 15% by early …

It is well established that ataxia-telangiectasia (AT) patients suffer a grossly elevated risk of
cancer, particularly lymphoma and leukaemia, but the possibility of an excess cancer risk of …

To date, the only reported genetic defect identified in the developmental disorder, Seckel
syndrome, is a mutation in ataxia telangiectasia and Rad3-related protein (ATR). Seckel …

Epidemiological studies have suggested that ataxia‐telangiectasia (AT) heterozygotes have
a predisposition to cancer, especially breast cancer in women. Now, haploty** can identify …

With improvements in supportive care and other therapeutic advances, children with
congenital or acquired immunodeficiencies are surviving longer. Unfortunately, with a more …

Ataxia‐telangiectasia (A‐T) is a pleiotropic inherited disease characterized by
neurodegeneration, cancer, immunodeficiencies, radiation sensitivity, and genetic instability …

Since the establishment of the United Nations Scientific Committee on the Effects of Atomic
Radiation by General Assembly resolution 913 (X) of 3 December 1955, the mandate of the …

Blood relatives of patients with the inherited disease ataxia telangiectasia (AT) have an
increased susceptibility for breast cancer. We therefore looked for sequence alterations of …

Acute myeloid leukemia (AML) is the result of a multistep transforming process of
hematopoietic precursor cells (HPCs) which enables them to proceed through limitless …