Mechanism of action of anti-hypercholesterolemia drugs and their resistance
V Tiwari, M Khokhar - European Journal of Pharmacology, 2014 - Elsevier
Coronary artery disease is one of the leading causes of death worldwide. One of the
significant causes of this disease is hypercholesterolemia which is the result of various …
significant causes of this disease is hypercholesterolemia which is the result of various …
[HTML][HTML] Criteria for diagnosis of familial hypercholesterolemia: a comprehensive analysis of the different guidelines, appraising their suitability in the Omani Arab …
Subjects with Familial hypercholesterolemia are at increased risk for cardiac events such as
premature myocardial infarction and early death from coronary heart disease, especially in …
premature myocardial infarction and early death from coronary heart disease, especially in …
Familial hypercholesterolemia mutations in the Middle Eastern and North African region: a need for a national registry
MA Bamimore, A Zaid, Y Banerjee, A Al-Sarraf… - Journal of clinical …, 2015 - Elsevier
Background Familial hypercholesterolemia (FH) is a well-understood Mendelian disorder
that increases the risk of cardiovascular disease (CVD), a leading cause of mortality in …
that increases the risk of cardiovascular disease (CVD), a leading cause of mortality in …
The gulf familial hypercholesterolemia registry (gulf FH): design, rationale and preliminary results
K Al-Rasadi, KF Alhabib, F Al-Allaf… - Current vascular …, 2020 - ingentaconnect.com
Aim: To determine the prevalence, genetic characteristics, current management and
outcomes of familial hypercholesterolaemia (FH) in the Gulf region. Methods: Adult (18-70 …
outcomes of familial hypercholesterolaemia (FH) in the Gulf region. Methods: Adult (18-70 …
Spectrum of mutations of familial hypercholesterolemia in the 22 Arab countries
D Alhababi, H Zayed - Atherosclerosis, 2018 - Elsevier
Background and aims Familial hypercholesterolemia (FH) is an inherited genetic disorder of
lipid metabolism characterized by a high serum LDL-cholesterol profile and xanthoma …
lipid metabolism characterized by a high serum LDL-cholesterol profile and xanthoma …
Identification and treatment of patients with homozygous familial hypercholesterolaemia: information and recommendations from a middle east advisory panel
A Al-Ashwal, F Alnouri, H Sabbour… - Current vascular …, 2015 - ingentaconnect.com
We present clinical practice guidelines for the diagnosis and treatment of homozygous
familial hypercholesterolaemia (HoFH) in the Middle East region. While guidelines are …
familial hypercholesterolaemia (HoFH) in the Middle East region. While guidelines are …
[HTML][HTML] Identification of a recurrent frameshift mutation at the LDLR exon 14 (c. 2027delG, p.(G676Afs* 33)) causing familial hypercholesterolemia in Saudi Arab …
FA Al-Allaf, A Alashwal, Z Abduljaleel, MM Taher… - Genomics, 2016 - Elsevier
Familial hypercholesterolemia (FH) is an autosomal dominant disease, predominantly
caused by variants in the low-density lipoprotein (LDL) receptor gene (LDLR). Herein, we …
caused by variants in the low-density lipoprotein (LDL) receptor gene (LDLR). Herein, we …
Lomitapide: navigating cardiovascular challenges with innovative therapies
U Munkhsaikhan, K Ait-Aissa, AM Sahyoun… - Molecular Biology …, 2024 - Springer
Dyslipidemia is the most significant risk factor for cardiovascular diseases (CVDs)
Secondary dyslipidemia: its treatments and association with atherosclerosis. Glob Health …
Secondary dyslipidemia: its treatments and association with atherosclerosis. Glob Health …
[HTML][HTML] Mutation in the PCSK9 gene in Omani Arab subjects with autosomal dominant hypercholesterolemia and its effect on PCSK9 protein structure
K Al-Waili, WAM Al-Zidi, AR Al-Abri… - Oman medical …, 2013 - ncbi.nlm.nih.gov
Proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL cholesterol
(LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor …
(LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor …
Ocular manifestations of severe familial hypercholesterolemia
AB Ghannam, R Istambouli, MS Hamam, JM Chalhoub… - Heliyon, 2024 - cell.com
Background To study ocular manifestations of patients with severe familial
hypercholesterolemia (FH). Methods In this population-based case-control study, patients …
hypercholesterolemia (FH). Methods In this population-based case-control study, patients …