The role of transcription factor 7‐like 2 in metabolic disorders
Summary Transcription factor 7‐like 2 (TCF7L2), a member of the T cell factor/lymphoid
enhancer factor family, generally forms a complex with β‐catenin to regulate the …
enhancer factor family, generally forms a complex with β‐catenin to regulate the …
[HTML][HTML] Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism
Abstract Objective Activation of the Wnt-signaling pathway is known to inhibit differentiation
in adipocytes. However, there is a gap in our understanding of the transcriptional network …
in adipocytes. However, there is a gap in our understanding of the transcriptional network …
Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism
Studies examining associations between purine metabolites and type 2 diabetes (T2D) are
limited. We prospectively examined associations between plasma levels of purine …
limited. We prospectively examined associations between plasma levels of purine …
Genetics of familial combined hyperlipidemia (FCHL) disorder: an update
E Taghizadeh, N Farahani, R Mardani, F Taheri… - Biochemical …, 2022 - Springer
Familial combined hyperlipidemia (FCHL) is one of the most common familial lipoprotein
disorders of the lipoproteins, with a prevalence of 0.5% to 2% in different populations. About …
disorders of the lipoproteins, with a prevalence of 0.5% to 2% in different populations. About …
Quantile-dependent expressivity of postprandial lipemia
PT Williams - PLoS One, 2020 - journals.plos.org
Purpose “Quantile-dependent expressivity” describes an effect of the genotype that depends
upon the level of the phenotype (eg, whether a subject's triglycerides are high or low relative …
upon the level of the phenotype (eg, whether a subject's triglycerides are high or low relative …
TCF7L2 gene associated postprandial triglyceride dysmetabolism- a novel mechanism for diabetes risk among Asian Indians
SV Madhu, BK Mishra, V Mannar, M Aslam… - Frontiers in …, 2022 - frontiersin.org
Aim TCF7L2 gene is believed to increase the risk of T2DM by its effects on insulin secretion.
However, the exact mechanism of this enhanced risk is not clearly known. While TCF7L2 …
However, the exact mechanism of this enhanced risk is not clearly known. While TCF7L2 …
Association of TCF7L2 Variants in Type 2 Diabetes Mellitus with Hypertriglyceridemia–A Case-Control Study
N Gunavathy, R Balaji, V Kumaravel - Indian Journal of …, 2023 - journals.lww.com
Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic condition involving
various genetic and environmental factors leading to impaired insulin secretion, resulting in …
various genetic and environmental factors leading to impaired insulin secretion, resulting in …
Investigating the association of rs7903146 of TCF7L2 gene, rs5219 of KCNJ11 gene, rs10946398 of CDKAL1 gene, and rs9939609 of FTO gene with type 2 diabetes …
Background Type 2 diabetes mellitus is a metabolic condition associated with increased risk
of multiple organ complications. Genetic variations in TCF7L2, KCNJ11, CDKAL1, and FTO …
of multiple organ complications. Genetic variations in TCF7L2, KCNJ11, CDKAL1, and FTO …
Transcription factor 7-like 2 single nucleotide polymorphisms are associated with lipid profile in the Balinese
Abstract Transcription factor 7-like 2 (TCF7L2) protein plays an important role in glucose and
lipid metabolisms. Single nucleotide polymorphisms (SNPs) in the TCF7L2 gene contribute …
lipid metabolisms. Single nucleotide polymorphisms (SNPs) in the TCF7L2 gene contribute …
No detectable effect of a type 2 diabetes-associated TCF7L2 genotype on the incretin effect
The T allele of TCF7L2 rs7903146 is a common genetic variant associated with type 2
diabetes (T2D), possibly by modulation of incretin action. In this study, we evaluated the …
diabetes (T2D), possibly by modulation of incretin action. In this study, we evaluated the …