Top-down inference in the auditory system: potential roles for corticofugal projections

A Asilador, DA Llano - Frontiers in Neural Circuits, 2021 - frontiersin.org
It has become widely accepted that humans use contextual information to infer the meaning
of ambiguous acoustic signals. In speech, for example, high-level semantic, syntactic, or …

Corticothalamic pathways in auditory processing: recent advances and insights from other sensory systems

FM Antunes, MS Malmierca - Frontiers in Neural Circuits, 2021 - frontiersin.org
The corticothalamic (CT) pathways emanate from either Layer 5 (L5) or 6 (L6) of the
neocortex and largely outnumber the ascending, thalamocortical pathways. The CT …

Sensory overamplification in layer 5 auditory corticofugal projection neurons following cochlear nerve synaptic damage

MM Asokan, RS Williamson, KE Hancock… - Nature …, 2018 - nature.com
Abstract Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to
coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a …

Hearing in complex environments: auditory gain control, attention, and hearing loss

BD Auerbach, HJ Gritton - Frontiers in neuroscience, 2022 - frontiersin.org
Listening in noisy or complex sound environments is difficult for individuals with normal
hearing and can be a debilitating impairment for those with hearing loss. Extracting …

Neural circuits underlying auditory contrast gain control and their perceptual implications

M Lohse, VM Bajo, AJ King, BDB Willmore - Nature Communications, 2020 - nature.com
Neural adaptation enables sensory information to be represented optimally in the brain
despite large fluctuations over time in the statistics of the environment. Auditory contrast gain …

[HTML][HTML] Recent advances in understanding the auditory cortex

AJ King, S Teki, BDB Willmore - F1000Research, 2018 - ncbi.nlm.nih.gov
Our ability to make sense of the auditory world results from neural processing that begins in
the ear, goes through multiple subcortical areas, and continues in the cortex. The specific …

What can we learn from inactivation studies? Lessons from auditory cortex

ZA Slonina, KC Poole, JK Bizley - Trends in Neurosciences, 2022 - cell.com
Inactivation experiments in auditory cortex (AC) produce widely varying results that
complicate interpretations regarding the precise role of AC in auditory perception and …

The associative thalamus: a switchboard for cortical operations and a promising target for schizophrenia

A Mukherjee, MM Halassa - The Neuroscientist, 2024 - journals.sagepub.com
Schizophrenia is a brain disorder that profoundly perturbs cognitive processing. Despite the
success in treating many of its symptoms, the field lacks effective methods to measure and …

When and how does the auditory cortex influence subcortical auditory structures? New insights about the roles of descending cortical projections

S Souffi, FR Nodal, VM Bajo, JM Edeline - Frontiers in Neuroscience, 2021 - frontiersin.org
For decades, the corticofugal descending projections have been anatomically well
described but their functional role remains a puzzling question. In this review, we will first …

[HTML][HTML] Listening in complex acoustic scenes

AJ King, KMM Walker - Current opinion in physiology, 2020 - Elsevier
Highlights•Sound perception in noisy environments is a major challenge for the auditory
system.•Adaptation to sound statistics helps to form noise-tolerant neural representations.• …