Heart failure plagues industrialized nations, killing more people than any other disease. It
usually results from a deficiency of specialized cardiac muscle cells known as …

The prospect of changing the plasticity of terminally differentiated cells toward pluripotency
has completely altered the outlook for biomedical research. Human-induced pluripotent …

Pluripotent stem cell–derived cardiomyocyte grafts can remuscularize substantial amounts
of infarcted myocardium and beat in synchrony with the heart, but in some settings cause …

Pluripotent stem cells provide a potential solution to current epidemic rates of heart failure by
providing human cardiomyocytes to support heart regeneration. Studies of human …

Despite preclinical studies demonstrating the functional benefit of transplanting human
pluripotent stem cell-derived cardiomyocytes (PSC-CMs) into damaged myocardium, the …

Transplantation studies in mice and rats have shown that human embryonic-stem-cell-
derived cardiomyocytes (hESC-CMs) can improve the function of infarcted hearts,,, but two …

Rationale: Tissue engineering approaches may improve survival and functional benefits
from human embryonic stem cell–derived cardiomyocyte transplantation, thereby potentially …

The ability of human pluripotent stem cells to form all cells of the body has provided many
opportunities to study disease and produce cells that can be used for therapy in …

We hypothesized that the neonatal rat heart would bring transplanted human induced
pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to maturity as it grows to adult …

Human heart failure due to myocardial infarction is a major health concern. The paucity of
organs for transplantation limits curative approaches for the diseased and failing adult heart …