Understanding the pathogenesis and clinical manifestations of systemic lupus
erythematosus (SLE) has been a great challenge. Reductionist approaches to understand …

Neural tube defects are severe congenital malformations affecting around one in every 1000
pregnancies. An innovation in clinical management has come from the finding that closure of …

In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator …

Gastrulation and neurulation are successive morphogenetic processes that play key roles in
sha** the basic embryonic body plan. Importantly, they operate through common cellular …

Planar cell polarity (PCP), the orientation and alignment of cells within a sheet, is a
ubiquitous cellular property that is commonly governed by the conserved set of proteins …

Neural tube defects (NTDs), including spina bifida and anencephaly, represent the most
severe and common malformations of the central nervous system affecting 0.7–3 per 1000 …

Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate
canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. In conjunction with Celsr …

Members of the Wnt family of secreted signaling proteins influence many aspects of neural
development and function. Wnts are required from neural induction and axis formation to …

Neurogenesis and tumorigenesis share signaling molecules/pathways involved in cell
proliferation, differentiation, migration, and death. Self-renewal of neural stem cells is a …

Studies of syndromic hydrocephalus have led to the identification of> 100 causative genes.
Even though this work has illuminated numerous pathways associated with hydrocephalus …