Targeting PI3K-AKT/mTOR signaling in the prevention of autism
A Sharma, S Mehan - Neurochemistry international, 2021 - Elsevier
Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …
for mammalian enzyme-related receptors in transducing signals or biological processes …
SARS-CoV-2 neuronal invasion and complications: potential mechanisms and therapeutic approaches
O Swain, SK Romano, R Miryala, J Tsai… - Journal of …, 2021 - Soc Neuroscience
Clinical reports suggest that the coronavirus disease-19 (COVID-19) pandemic caused by
severe acute respiratory syndrome (SARS)-coronavirus-2 (CoV-2) has not only taken …
severe acute respiratory syndrome (SARS)-coronavirus-2 (CoV-2) has not only taken …
Identification of ligand–receptor pairs that drive human astrocyte development
Extrinsic signaling between diverse cell types is crucial for nervous system development.
Ligand binding is a key driver of developmental processes. Nevertheless, it remains a …
Ligand binding is a key driver of developmental processes. Nevertheless, it remains a …
[HTML][HTML] Autistic spectrum disorder (ASD)–Gene, molecular and pathway signatures linking systemic inflammation, mitochondrial dysfunction, transsynaptic signalling …
Background Despite advances in autism spectrum disorder (ASD) research and the vast
genomic, transcriptomic, and proteomic data available, there are still controversies …
genomic, transcriptomic, and proteomic data available, there are still controversies …
Activation of cell-free mtDNA-TLR9 signaling mediates chronic stress-induced social behavior deficits
Inflammation and social behavior deficits are associated with a number of neuropsychiatric
disorders. Chronic stress, a major risk factor for depression and other mental health …
disorders. Chronic stress, a major risk factor for depression and other mental health …
Tau reduction prevents key features of autism in mouse models
Autism is characterized by repetitive behaviors, impaired social interactions, and
communication deficits. It is a prevalent neurodevelopmental disorder, and available …
communication deficits. It is a prevalent neurodevelopmental disorder, and available …
Mechanisms underlying the cognitive and behavioural effects of maternal obesity
The widespread consumption of 'western'-style diets along with sedentary lifestyles has led
to a global epidemic of obesity. Epidemiological, clinical and preclinical evidence suggests …
to a global epidemic of obesity. Epidemiological, clinical and preclinical evidence suggests …
Loss of Cntnap2 in the Rat Causes Autism‐Related Alterations in Social Interactions, Stereotypic Behavior, and Sensory Processing
Autism spectrum disorder (ASD) is characterized by social interaction and communication
impairments, as well as restrictive/repetitive patterns of behavior, interests or activities, which …
impairments, as well as restrictive/repetitive patterns of behavior, interests or activities, which …
Dysregulation of neurite outgrowth and cell migration in autism and other neurodevelopmental disorders
S Prem, JH Millonig, E DiCicco-Bloom - … Disorders: Employing iPSC …, 2020 - Springer
Despite decades of study, elucidation of the underlying etiology of complex developmental
disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ), intellectual …
disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ), intellectual …
Autism spectrum disorder and a possible role of anti-inflammatory treatments: experience in the pediatric allergy/immunology clinic
H Jyonouchi - Frontiers in Psychiatry, 2024 - frontiersin.org
Autism spectrum disorder (ASD1) is a behaviorally defined syndrome encompassing a
markedly heterogeneous patient population. Many ASD subjects fail to respond to the 1st …
markedly heterogeneous patient population. Many ASD subjects fail to respond to the 1st …