The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that
orchestrates an attack on the motor nervous system that is unrelenting. Recent discoveries …

In patients with amyotrophic lateral sclerosis (ALS), disease symptoms and pathology
typically spread in a predictable spatiotemporal pattern beginning at a focal site of onset and …

Mutations in SOD1 cause amyotrophic lateral sclerosis (ALS), a neurodegenerative disease
characterized by motor neuron (MN) loss. We previously discovered that macrophage …

Multiple neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parkinson's
disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) are being …

Mitochondria participate in essential processes in the nervous system such as energy and
intermediate metabolism, calcium homeostasis, and apoptosis. Major neurodegenerative …

Impaired mitochondrial function has been proposed as a causative factor in
neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), caused by motor …

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a fatal
neurodegenerative disease caused by the progressive loss of motor neurons in the brain …

Abstract NADPH oxidase 4 (NOX4) regulates endothelial inflammation by producing
hydrogen peroxide (H 2 O 2) and to a lesser extent O 2•-. The ratio of NOX4-derived H 2 O 2 …

Abstract Background Upper motor neurons (UMNs) are a key component of motor neuron
circuitry. Their degeneration is a hallmark for diseases, such as hereditary spastic …