Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Hypoxia-inducible factor signaling in pulmonary hypertension
Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can
subsequently culminate in right heart failure and premature death. Emerging evidence …
subsequently culminate in right heart failure and premature death. Emerging evidence …
Human high-altitude adaptation: forward genetics meets the HIF pathway
Humans have adapted to the chronic hypoxia of high altitude in several locations, and
recent genome-wide studies have indicated a genetic basis. In some populations, genetic …
recent genome-wide studies have indicated a genetic basis. In some populations, genetic …
Phase I dose-escalation trial of PT2385, a first-in-class hypoxia-inducible factor-2α antagonist in patients with previously treated advanced clear cell renal cell …
Purpose The von Hippel-Lindau tumor suppressor is inactivated in the majority of clear cell
renal cell carcinomas (ccRCCs), leading to inappropriate stabilization of hypoxia-inducible …
renal cell carcinomas (ccRCCs), leading to inappropriate stabilization of hypoxia-inducible …
High-altitude adaptation: mechanistic insights from integrated genomics and physiology
Population genomic analyses of high-altitude humans and other vertebrates have identified
numerous candidate genes for hypoxia adaptation, and the physiological pathways …
numerous candidate genes for hypoxia adaptation, and the physiological pathways …
Measuring high-altitude adaptation
High altitudes (> 8,000 ft or 2,500 m) provide an experiment of nature for measuring
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …
Pulmonary hypertension in acute and chronic high altitude maladaptation disorders
Alveolar hypoxia is the most prominent feature of high altitude environment with well-known
consequences for the cardio-pulmonary system, including development of pulmonary …
consequences for the cardio-pulmonary system, including development of pulmonary …
The increase in hemoglobin concentration with altitude varies among human populations
M Gassmann, H Mairbäurl, L Livshits… - Annals of the New …, 2019 - Wiley Online Library
Decreased oxygen availability at high altitude requires physiological adjustments allowing
for adequate tissue oxygenation. One such mechanism is a slow increase in the hemoglobin …
for adequate tissue oxygenation. One such mechanism is a slow increase in the hemoglobin …
Long-term genetic stability and a high-altitude East Asian origin for the peoples of the high valleys of the Himalayan arc
The high-altitude transverse valleys [> 3,000 m above sea level (masl)] of the Himalayan arc
from Arunachal Pradesh to Ladahk were among the last habitable places permanently …
from Arunachal Pradesh to Ladahk were among the last habitable places permanently …
King of the mountains: Tibetan and Sherpa physiological adaptations for life at high altitude
Anecdotal evidence surrounding Tibetans' and Sherpas' exceptional tolerance to hypobaric
hypoxia has been recorded since the beginning of high-altitude exploration. These …
hypoxia has been recorded since the beginning of high-altitude exploration. These …
Altitude adaptation: a glimpse through various lenses
TS Simonson - High altitude medicine & biology, 2015 - liebertpub.com
Abstract Simonson, Tatum S. Altitude adaptation: A glimpse through various lenses. High Alt
Med Biol 16: 125–137, 2015.—Recent availability of genome-wide data from highland …
Med Biol 16: 125–137, 2015.—Recent availability of genome-wide data from highland …