Propionic acidemia (PA) is a genetic metabolic disorder caused by mutations in the
mitochondrial enzyme, propionyl-CoA carboxylase (PCC), which is responsible for …

Clinical observations and experimental studies have determined that systemic acid-base
disturbances can profoundly affect the heart. A wealth of information is available on the …

Aims Maladaptive ventricular remodeling is a major cause of ventricular arrhythmias
following myocardial infarction (MI) and adversely impacts the quality of life of affected …

Propionic acidemia (PA) is a rare autosomal-recessive metabolic disease that arises from
mutations in propionyl-CoA (C3-CoA) carboxylase. Reduced enzyme activity slows C3-CoA …

Propionic acidemia (PA), arising from PCCA or PCCB variants, manifests as life-threatening
cardiomyopathy and arrhythmias, with unclear pathophysiology. In this work, propionyl-CoA …

Abstract Propionic acidemia (PA, OMIM 606054) is a devastating inborn error of metabolism
arising from mutations that reduce the activity of the mitochondrial enzyme propionyl‐CoA …

Propionic acidemia (PA) is an autosomal recessive metabolic disorder after gene encoding
propionyl-CoA carboxylase, Pcca or Pccb, is mutated. This genetic disorder could develop …

Ca2+ mishandling is a common feature in several cardiovascular diseases such as heart
failure (HF). In many cases, impairment of key players in intracellular Ca2+ homeostasis has …

Atrial fibrillation (AF) is a supraventricular arrhythmia deriving from uncoordinated electrical
activation with considerable associated morbidity and mortality. To expand the limited …

Heart and kidney have a closely interrelated pathophysiology. Acute kidney injury (AKI) is
associated with significantly increased rates of cardiovascular events, a relationship defined …