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Overcoming cancer therapeutic bottleneck by drug repurposing
Z Zhang, L Zhou, N ** workflows to link chemicals with bioactivities
Screening new compounds for potential bioactivities against cellular targets is vital for drug
discovery and chemical safety. Transcriptomics offers an efficient approach for assessing …
discovery and chemical safety. Transcriptomics offers an efficient approach for assessing …
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action
Assays to study cancer cell responses to pharmacologic or genetic perturbations are
typically restricted to using simple phenotypic readouts such as proliferation rate. Information …
typically restricted to using simple phenotypic readouts such as proliferation rate. Information …
Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection
Mitochondrial toxicity is an important safety endpoint in drug discovery. Models based solely
on chemical structure for predicting mitochondrial toxicity are currently limited in accuracy …
on chemical structure for predicting mitochondrial toxicity are currently limited in accuracy …
Predicting cell health phenotypes using image-based morphology profiling
Genetic and chemical perturbations impact diverse cellular phenotypes, including multiple
indicators of cell health. These readouts reveal toxicity and antitumorigenic effects relevant …
indicators of cell health. These readouts reveal toxicity and antitumorigenic effects relevant …
[HTML][HTML] Electrospun fibres of chitosan/PVP for the effective chemotherapeutic drug delivery of 5-fluorouracil
Electrospun nanofibrous mats consisting of chitosan (CS) and polyvinylpyrrolidone (PVP)
were constructed. Tuning of solution and process parameters was performed and resulted in …
were constructed. Tuning of solution and process parameters was performed and resulted in …
From pixels to phenotypes: Integrating image-based profiling with cell health data as BioMorph features improves interpretability
Cell Painting assays generate morphological profiles that are versatile descriptors of
biological systems and have been used to predict in vitro and in vivo drug effects. However …
biological systems and have been used to predict in vitro and in vivo drug effects. However …
[HTML][HTML] A community challenge for a pancancer drug mechanism of action inference from perturbational profile data
Summary The Columbia Cancer Target Discovery and Development (CTD2) Center is
develo** PANACEA, a resource comprising dose-responses and RNA sequencing (RNA …
develo** PANACEA, a resource comprising dose-responses and RNA sequencing (RNA …
Assessment of modelling strategies for drug response prediction in cell lines and xenografts
Data from several large high-throughput drug response screens have become available to
the scientific community recently. Although many efforts have been made to use this …
the scientific community recently. Although many efforts have been made to use this …