Genetic contributions to autism spectrum disorder

A Havdahl, M Niarchou, A Starnawska… - Psychological …, 2021 - cambridge.org
Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental
conditions characterized by early childhood-onset impairments in communication and social …

Schizophrenia genomics: genetic complexity and functional insights

PF Sullivan, S Yao, J Hjerling-Leffler - Nature Reviews Neuroscience, 2024 - nature.com
Determining the causes of schizophrenia has been a notoriously intractable problem,
resistant to a multitude of investigative approaches over centuries. In recent decades …

The brain is adaptive not triune: How the brain responds to threat, challenge, and change

PR Steffen, D Hedges, R Matheson - Frontiers in psychiatry, 2022 - frontiersin.org
Theory impacts how research is conducted. A popular theory used to conceptualize brain
functioning is the triune brain theory. The triune brain theory is an evolutionary theory of …

[HTML][HTML] Autistic spectrum disorder (ASD)–Gene, molecular and pathway signatures linking systemic inflammation, mitochondrial dysfunction, transsynaptic signalling …

M Gevezova, Y Sbirkov, V Sarafian, K Plaimas… - Brain, behavior, & …, 2023 - Elsevier
Background Despite advances in autism spectrum disorder (ASD) research and the vast
genomic, transcriptomic, and proteomic data available, there are still controversies …

[HTML][HTML] Copy number variation and neuropsychiatric illness

E Rees, G Kirov - Current Opinion in Genetics & Development, 2021 - Elsevier
Copy number variants (CNVs) at specific loci have been identified as important risk factors
for several neuropsychiatric disorders, such as schizophrenia, autism spectrum disorder …

The parvalbumin hypothesis of autism spectrum disorder

F Filice, L Janickova, T Henzi, A Bilella… - Frontiers in Cellular …, 2020 - frontiersin.org
The prevalence of autism spectrum disorder (ASD)—a type of neurodevelopmental disorder—
is increasing and is around 2% in North America, Asia, and Europe. Besides the known …

[HTML][HTML] Transcriptomic insight into the polygenic mechanisms underlying psychiatric disorders

LM Hernandez, M Kim, GD Hoftman, JR Haney… - Biological …, 2021 - Elsevier
Over the past decade, large-scale genetic studies have successfully identified hundreds of
genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic …

[HTML][HTML] Isolation disrupts social interactions and destabilizes brain development in bumblebees

ZY Wang, GC McKenzie-Smith, W Liu, HJ Cho… - Current Biology, 2022 - cell.com
Social isolation, particularly in early life, leads to deleterious physiological and behavioral
outcomes. Here, we leverage new high-throughput tools to comprehensively investigate the …

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13. 3 microdeletion syndrome

BK Unda, L Chalil, S Yoon, S Kilpatrick, C Irwin… - Molecular …, 2023 - nature.com
Copy number variations (CNVs) are associated with psychiatric and neurodevelopmental
disorders (NDDs), and most, including the recurrent 15q13. 3 microdeletion disorder, have …

[HTML][HTML] Neuroimaging findings in neurodevelopmental copy number variants: identifying molecular pathways to convergent phenotypes

AI Silva, F Ehrhart, MO Ulfarsson, H Stefansson… - Biological …, 2022 - Elsevier
Genomic copy number variants (CNVs) are associated with a high risk of
neurodevelopmental disorders. A growing body of genetic studies suggests that these high …