The realisation that new chemical entities under development as drug candidates fail in
three of four cases in clinical trials, together with increased costs and increased demands of …

The importance of in-depth knowledge about the pharmacokinetics of a drug is evident
because pharmacokinetic behaviour may correlate with activity and toxicity. The most …

Daflon 500® mg, is a micronized purified flavonoid fraction, containing 90% w/w diosmin
and 10% w/w of flavonoids expressed as hesperidin, used clinically in the treatment of …

Thoroughly revised and updated, Handbook of Vitamins highlights the recent research in
vitamins and gene expression, vitamin-dependent genes, and vitamin effect on DNA …

Testing the safety and efficacy of a successful human medicine involves many laboratory
animals, which can sometimes be subjected to considerable suffering and distress. Also, it is …

The effect of food composition on the digestive system of Penaeus vannamei shrimp was
used to determine the suitability of feces for analysis of class, type, composition of digestive …

The increasing role of accelerator mass spectrometry (AMS) in biomedical research
necessitates modernization of the traditional sample handling process. AMS was originally …

Microdosing as a regulatory concept was introduced to facilitate exploratory studies in
humans. The concept involves the use of very low doses of a radionuclide-labeled …

Abstract Vismodegib (GDC-0449), a small-molecule Hedgehog pathway inhibitor, was well
tolerated in patients with solid tumors and showed promising efficacy in advanced basal cell …

Accelerator mass spectrometry (AMS) is an extremely sensitive nuclear physics technique
developed in the mid-70's for radiocarbon dating of historical artefacts. The technique …