The last 50 years have witnessed extraordinary developments in understanding
mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical …

Epigenetic regulation established during development to maintain patterns of transcriptional
expression and silencing for metabolism and other fundamental cell processes can be …

Background Bladder cancer (BLCA) is the most common malignancy of the urinary tract. On
the other hand, disulfidptosis, a mechanism of disulfide stress-induced cell death, is closely …

Background Ovarian cancer (OC) is one of the most common and most malignant
gynecological malignancies in gynecology. On the other hand, dysregulation of copper …

Abstract l-Lactate is increasingly appreciated as a key metabolite and signaling molecule in
mammals. However, investigations of the inter-and intra-cellular dynamics of l-lactate are …

Tumor cells elicit metabolic reprogramming to establish an immunosuppressive tumor
microenvironment (TME) for esca** from immunosurveillance. Therefore, interrupting the …

In the challenging tumor microenvironment (TME), tumors coexist with diverse stromal cell
types. During tumor progression and metastasis, a reciprocal interaction occurs between …

Background Glioblastoma (GBM) is a malignant primary brain tumor. This study focused on
exploring the exosome-related features of glioblastoma to better understand its cellular …

Simple Summary Several studies have highlighted the importance of the myeloid receptor
CSF-1R in the context of tumors as a key player in the generation of an immunosuppressive …

The phenomenon of T Cell exhaustion (TEX) entails a progressive deterioration in the
functionality of T cells within the immune system during prolonged conflicts with chronic …