▪ Abstract The maintenance of the eukaryotic genome requires precisely coordinated
replication of the entire genome each time a cell divides. To achieve this coordination …

The minichromosome maintenance (or MCM) protein family is composed of six related
proteins that are conserved in all eukaryotes. They were first identified by genetic screens in …

The minichromosome maintenance (MCM) 2-7 helicase complex functions to initiate and
elongate replication forks. Cell cycle checkpoint signaling pathways regulate DNA …

The exact duplication of a genome once per cell division is required of every proliferating
cell. To achieve this goal, eukaryotes adopt a strategy that limits every replication origin to a …

Mammalian DNA replication is an elegantly choreographed process in which multiple
components are assembled at the origins to form the prereplication complex. Formation and …

Initiation and completion of DNA replication defines the beginning and ending of S phase of
the cell cycle. Successful progression through S phase requires that replication be properly …

The MCM2-7 helicase complex is loaded on DNA replication origins during the G1 phase of
the cell cycle to license the origins for replication in S phase. How the initiator primase …

Mcm10 is a conserved eukaryotic DNA replication factor whose function has remained
elusive. We report here that Mcm10 binding to replication origins in budding yeast is cell …

The hardest part of replicating a genome is the beginning. The first step of DNA replication
(called “initiation”) mobilizes a large number of specialized proteins (“initiators”) that …

Current models suggest that the replication initiation factor Mcm10 is required for
association of Mcm2-7 with origins of replication to generate the prereplicative complex (pre …