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Accurate prediction of HLA class II antigen presentation across all loci using tailored data acquisition and refined machine learning
JB Nilsson, S Kaabinejadian, H Yari, MGD Kester… - Science …, 2023 - science.org
Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II
molecules is crucial for rational development of immunotherapies and vaccines targeting …
molecules is crucial for rational development of immunotherapies and vaccines targeting …
[HTML][HTML] Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
J Racle, P Guillaume, J Schmidt, J Michaux, A Larabi… - Immunity, 2023 - cell.com
CD4+ T cells orchestrate the adaptive immune response against pathogens and cancer by
recognizing epitopes presented on class II major histocompatibility complex (MHC-II) …
recognizing epitopes presented on class II major histocompatibility complex (MHC-II) …
[HTML][HTML] From clones to immunopeptidomes: new developments in the characterization of permissive HLA-DP mismatches in hematopoietic cell transplantation
E Arrieta-Bolaños - Best Practice & Research Clinical Haematology, 2024 - Elsevier
Mismatching at the HLA-DPB1 locus occurs frequently in hematopoietic cell transplantation
with unrelated donors. Despite this, HLA-DPB1 allelic mismatches have traditionally not …
with unrelated donors. Despite this, HLA-DPB1 allelic mismatches have traditionally not …
Tricking the trickster: precision medicine approaches to counteract leukemia immune escape after transplant
A Tameni, C Toffalori, L Vago - Blood, 2024 - ashpublications.org
Over the last decades, significant improvements in reducing the toxicities of allogeneic
hematopoietic cell transplantation (allo-HCT) have widened its use as consolidation or …
hematopoietic cell transplantation (allo-HCT) have widened its use as consolidation or …
Impact of the HLA immunopeptidome on survival of leukemia patients after unrelated donor transplantation
PURPOSE Immunopeptidome divergence between mismatched HLA-DP is a determinant of
T-cell alloreactivity and clinical tolerability after fully HLA-A,-B,-C,-DRB1,-DQB1 matched …
T-cell alloreactivity and clinical tolerability after fully HLA-A,-B,-C,-DRB1,-DQB1 matched …
Human leukocyte antigen mismatching and survival in contemporary hematopoietic cell transplantation for hematologic malignancies
PURPOSE Human leukocyte antigen (HLA) mismatching can reduce survival of patients
with blood cancer after hematopoietic cell transplantation (HCT). How recent advances in …
with blood cancer after hematopoietic cell transplantation (HCT). How recent advances in …
Integrated multiomic profiling identifies the epigenetic regulator PRC2 as a therapeutic target to counteract leukemia immune escape and relapse
V Gambacorta, S Beretta, M Ciccimarra, L Zito… - Cancer …, 2022 - aacrjournals.org
Immune escape represents a major driver of acute myeloid leukemia (AML) reemergence
after allogeneic hematopoietic cell transplantation (allo-HCT), with up to 40% of relapses …
after allogeneic hematopoietic cell transplantation (allo-HCT), with up to 40% of relapses …
A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation
Clinically tolerable, permissive HLA-DPB1 mismatches defined by the T-cell epitope (TCE)
model improve the selection of unrelated donors in allogeneic hematopoietic cell …
model improve the selection of unrelated donors in allogeneic hematopoietic cell …
Impact of CMV reactivation on relapse of acute myeloid leukemia after HCT is dependent on disease stage and ATG
AT Turki, N Tsachakis-Mück, S Leserer… - Blood …, 2022 - ashpublications.org
Cytomegalovirus (CMV) reactivation is a frequent complication after allogeneic
hematopoietic cell transplantation (HCT), whose impact on clinical outcome, in particular on …
hematopoietic cell transplantation (HCT), whose impact on clinical outcome, in particular on …
Inflammatory CD4/CD8 double-positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology
An important paradigm in allogeneic hematopoietic cell transplantations (allo-HCTs) is the
prevention of graft-versus-host disease (GVHD) while preserving the graft-versus-leukemia …
prevention of graft-versus-host disease (GVHD) while preserving the graft-versus-leukemia …