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Protein sorting from endosomes to the TGN
Retrograde transport from endosomes to the trans-Golgi network is essential for recycling of
protein and lipid cargoes to counterbalance anterograde membrane traffic. Protein cargo …
protein and lipid cargoes to counterbalance anterograde membrane traffic. Protein cargo …
[HTML][HTML] Cargo Sorting at the trans-Golgi Network for Shunting into Specific Transport Routes: Role of Arf Small G Proteins and Adaptor Complexes
The trans-Golgi network (TGN) is responsible for selectively recruiting newly synthesized
cargo into transport carriers for delivery to their appropriate destination. In addition, the TGN …
cargo into transport carriers for delivery to their appropriate destination. In addition, the TGN …
AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation
AP-4 is a member of the heterotetrameric adaptor protein (AP) complex family involved in
protein sorting in the endomembrane system of eukaryotic cells. Interest in AP-4 has recently …
protein sorting in the endomembrane system of eukaryotic cells. Interest in AP-4 has recently …
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
Abstract Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose
function has largely remained elusive. In humans, AP-4 deficiency causes a severe …
function has largely remained elusive. In humans, AP-4 deficiency causes a severe …
AP-4-mediated axonal transport controls endocannabinoid production in neurons
The adaptor protein complex AP-4 mediates anterograde axonal transport and is essential
for axon health. AP-4-deficient patients suffer from a severe neurodevelopmental and …
for axon health. AP-4-deficient patients suffer from a severe neurodevelopmental and …
Proteomic characterization of isolated Arabidopsis clathrin-coated vesicles reveals evolutionarily conserved and plant-specific components
In eukaryotes, clathrin-coated vesicles (CCVs) facilitate the internalization of material from
the cell surface as well as the movement of cargo in post-Golgi trafficking pathways. This …
the cell surface as well as the movement of cargo in post-Golgi trafficking pathways. This …
EPSIN1 and MTV1 define functionally overlap** but molecularly distinct trans-Golgi network subdomains in Arabidopsis
The plant trans-Golgi network (TGN) is a central trafficking hub where secretory, vacuolar,
recycling, and endocytic pathways merge. Among currently known molecular players …
recycling, and endocytic pathways merge. Among currently known molecular players …
Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome
Adaptor protein (AP) complexes mediate key sorting decisions in the cell through selective
incorporation of transmembrane proteins into vesicles. Little is known of the roles of AP-4 …
incorporation of transmembrane proteins into vesicles. Little is known of the roles of AP-4 …
[HTML][HTML] Evolutionary origins and specialisation of membrane transport
From unicellular protists to the largest megafauna and flora, all eukaryotes depend upon the
organelles and processes of the intracellular membrane trafficking system. Well-defined …
organelles and processes of the intracellular membrane trafficking system. Well-defined …
[HTML][HTML] AP-4-associated hereditary spastic paraplegia
D Ebrahimi-Fakhari, R Behne, AK Davies, J Hirst - 2018 - europepmc.org
AP-4-associated hereditary spastic paraplegia (HSP), also known as AP-4 deficiency
syndrome, is a group of neurodegenerative disorders characterized by a progressive …
syndrome, is a group of neurodegenerative disorders characterized by a progressive …