Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage
Insulin resistance contributes to the pathophysiology of diabetes and is a hallmark of
obesity, metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying …
obesity, metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying …
Diabetes: models, signals, and control
The control of diabetes is an interdisciplinary endeavor, which includes a significant
biomedical engineering component, with traditions of success beginning in the early 1960s …
biomedical engineering component, with traditions of success beginning in the early 1960s …
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity
Obesity is accompanied by numerous systemic and tissue-specific derangements, including
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …
Novel insights into glucocorticoid‐mediated diabetogenic effects: towards expansion of therapeutic options?
DH Van Raalte, DM Ouwens… - European journal of …, 2009 - Wiley Online Library
At pharmacological concentrations, glucocorticoids (GCs) display potent anti‐inflammatory
effects, and are therefore frequently prescribed by physicians to treat a wide variety of …
effects, and are therefore frequently prescribed by physicians to treat a wide variety of …
Assessment of pancreatic β-cell function: review of methods and clinical applications
E Cersosimo, C Solis-Herrera… - Current diabetes …, 2014 - ingentaconnect.com
Type 2 diabetes mellitus (T2DM) is characterized by a progressive failure of pancreatic β-
cell function (BCF) with insulin resistance. Once insulin over-secretion can no longer …
cell function (BCF) with insulin resistance. Once insulin over-secretion can no longer …
[HTML][HTML] Role of reduced β-cell mass versus impaired β-cell function in the pathogenesis of type 2 diabetes
JJ Meier, RC Bonadonna - Diabetes care, 2013 - ncbi.nlm.nih.gov
Although it has long been assumed that insulin resistance is the leading factor in the
pathogenesis of type 2 diabetes (1), evidence for the importance of the pancreatic β-cells …
pathogenesis of type 2 diabetes (1), evidence for the importance of the pancreatic β-cells …
Diabetes and beta cell function: from mechanisms to evaluation and clinical implications
Sažetak Diabetes is a complex, heterogeneous condition that has beta cell dysfunction at its
core. Many factors (eg hyperglycemia/glucotoxicity, lipotoxicity, autoimmunity, inflammation …
core. Many factors (eg hyperglycemia/glucotoxicity, lipotoxicity, autoimmunity, inflammation …
Diurnal pattern to insulin secretion and insulin action in healthy individuals
Evaluation of the existence of a diurnal pattern of glucose tolerance after mixed meals is
important to inform a closed-loop system of treatment for insulin requiring diabetes. We …
important to inform a closed-loop system of treatment for insulin requiring diabetes. We …
Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test
R Retnakaran, S Shen, AJ Hanley, V Vuksan… - …, 2008 - Wiley Online Library
The utility of the disposition index as a measure of β‐cell compensatory capacity rests on the
established hyperbolic relationship between its component insulin secretion and sensitivity …
established hyperbolic relationship between its component insulin secretion and sensitivity …
The oral minimal model method
The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to
understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We …
understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We …