The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics

D Bautista-Sánchez, C Arriaga-Canon… - … therapy Nucleic acids, 2020 - cell.com
MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene
expression via base-pairing complementarity. Their role in cancer can be related to tumor …

Functional interactions among microRNAs and long noncoding RNAs

JH Yoon, K Abdelmohsen, M Gorospe - Seminars in cell & developmental …, 2014 - Elsevier
In mammals, the vast majority of transcripts expressed are noncoding RNAs, ranging from
short RNAs (including microRNAs) to long RNAs spanning up to hundreds of kb. While the …

[HTML][HTML] Ionizing radiation-induced epigenetic modifications and their relevance to radiation protection

M Belli, MA Tabocchini - International journal of molecular sciences, 2020 - mdpi.com
The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …

Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer

P Dogra, V Shinglot, J Ruiz-Ramírez, J Cave… - Molecular cancer, 2024 - Springer
Abstract Background Elevated microRNA-155 (miR-155) expression in non-small-cell lung
cancer (NSCLC) promotes cisplatin resistance and negatively impacts treatment outcomes …

Understanding microRNA-mediated gene regulatory networks through mathematical modelling

X Lai, O Wolkenhauer, J Vera - Nucleic acids research, 2016 - academic.oup.com
The discovery of microRNAs (miRNAs) has added a new player to the regulation of gene
expression. With the increasing number of molecular species involved in gene regulatory …

Circulating cell-free microRNAs as clinical cancer biomarkers

V Armand-Labit, A Pradines - Biomolecular concepts, 2017 - degruyter.com
MicroRNAs (miRNAs) are non-coding small RNAs that are master regulators of genic
expression and consequently of many cellular processes. But their expression is often …

Deciphering the role of miRNA in reprogramming plant responses to drought stress

A Singh, D Jain, J Pandey, M Yadav… - Critical reviews in …, 2023 - Taylor & Francis
Drought is the most prevalent environmental stress that affects plants' growth, development,
and crop productivity. However, plants have evolved adaptive mechanisms to respond to the …

A state-of-the-art review on the MicroRNAs roles in hematopoietic stem cell aging and longevity

GGR Ortiz, Y Mohammadi, A Nazari… - Cell Communication and …, 2023 - Springer
Aging is a biological process determined through time-related cellular and functional
impairments, leading to a decreased standard of living for the organism. Recently, there has …

Trophoblast derived extracellular vesicles specifically alter the transcriptome of endometrial cells and may constitute a critical component of embryo-maternal …

K Godakumara, J Ord, F Lättekivi… - Reproductive Biology …, 2021 - Springer
Background The period of time when the embryo and the endometrium undergo significant
morphological alterations to facilitate a successful implantation—known as “window of …

Interplay of microRNAs, transcription factors and target genes: linking dynamic expression changes to function

PV Nazarov, SE Reinsbach, A Muller… - Nucleic acids …, 2013 - academic.oup.com
MicroRNAs (miRNAs) are ubiquitously expressed small non-coding RNAs that, in most
cases, negatively regulate gene expression at the post-transcriptional level. miRNAs are …