Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas
(DMGs) are universally lethal paediatric tumours of the central nervous system. We have …

O-GlcNAc is a dynamic post-translational modification (PTM) that regulates protein functions.
In studying the regulatory roles of O-GlcNAc, a major roadblock is the inability to change O …

The lung microvasculature is essential for gas exchange and commonly considered
homogeneous. We show that VEGFA from the epithelium is required for a distinct …

As the size and complexity of high‐dimensional (HD) cytometry data continue to expand,
comprehensive, scalable, and methodical computational analysis approaches are essential …

Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic
form of regulated cell death that has been implicated in maladaptive renal repair in mice and …

Skin color is highly variable in Africans, yet little is known about the underlying molecular
mechanism. Here we applied massively parallel reporter assays to screen 1,157 candidate …

Immunotherapy is improving the prognosis and survival of cancer patients, but despite
encouraging outcomes in different cancers, the majority of tumors are resistant to it, and the …

In inflamed tissues, monocytes differentiate into macrophages (mo-Macs) or dendritic cells
(mo-DCs). In chronic nonresolving inflammation, mo-DCs are major drivers of pathogenic …

Long-term sequelae of coronavirus disease (COVID)-19 are frequent and of major concern.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the host …

The activating receptor CD226 is expressed on lymphocytes, monocytes, and platelets and
promotes anti-tumor immunity in pre-clinical models. Here, we examined the role of CD226 …