Function and biogenesis of lipopolysaccharides
The cell envelope is the first line of defense between a bacterium and the world-at-large.
Often, the initial steps that determine the outcome of chemical warfare, bacteriophage …
Often, the initial steps that determine the outcome of chemical warfare, bacteriophage …
Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model
Gram-negative bacteria have a double-membrane cellular envelope that enables them to
colonize harsh environments and prevents the entry of many clinically available antibiotics …
colonize harsh environments and prevents the entry of many clinically available antibiotics …
A new antibiotic traps lipopolysaccharide in its intermembrane transporter
Gram-negative bacteria are extraordinarily difficult to kill because their cytoplasmic
membrane is surrounded by an outer membrane that blocks the entry of most antibiotics …
membrane is surrounded by an outer membrane that blocks the entry of most antibiotics …
Biosynthesis and export of bacterial lipopolysaccharides
C Whitfield, MS Trent - Annual review of biochemistry, 2014 - annualreviews.org
Lipopolysaccharide molecules represent a unique family of glycolipids based on a highly
conserved lipid moiety known as lipid A. These molecules are produced by most gram …
conserved lipid moiety known as lipid A. These molecules are produced by most gram …
Designing of multi-epitope peptide vaccine against Acinetobacter baumannii through combined immunoinformatics and protein interaction–based approaches
Acinetobacter baumannii is one of the major pathogenic ESKAPE bacterium, which is
responsible for about more than 722,000 cases in a year, globally. Despite the alarming …
responsible for about more than 722,000 cases in a year, globally. Despite the alarming …
Assembly and maintenance of lipids at the bacterial outer membrane
The outer membrane of Gram-negative bacteria is essential for their survival in harsh
environments and provides intrinsic resistance to many antibiotics. This membrane is …
environments and provides intrinsic resistance to many antibiotics. This membrane is …
Prospects for new antibiotics: a molecule-centered perspective
There is a continuous need for iterative cycles of antibiotic discovery and development to
deal with the selection of resistant pathogens that emerge as therapeutic application of an …
deal with the selection of resistant pathogens that emerge as therapeutic application of an …
Structure of a nascent membrane protein as it folds on the BAM complex
Mitochondria, chloroplasts and Gram-negative bacteria are encased in a double layer of
membranes. The outer membrane contains proteins with a β-barrel structure,. β-Barrels are …
membranes. The outer membrane contains proteins with a β-barrel structure,. β-Barrels are …
Structural basis for lipopolysaccharide insertion in the bacterial outer membrane
One of the fundamental properties of biological membranes is the asymmetric distribution of
membrane lipids. In Gram-negative bacteria, the outer leaflet of the outer membrane is …
membrane lipids. In Gram-negative bacteria, the outer leaflet of the outer membrane is …
Structural basis for outer membrane lipopolysaccharide insertion
Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria and has crucial roles
in protection of the bacteria from harsh environments and toxic compounds, including …
in protection of the bacteria from harsh environments and toxic compounds, including …