ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

Simple Summary Deregulation of the FGF/FGFR axis is associated with many types of
cancer and contributes to the development of chemoresistance, limiting the effectiveness of …

Background Pancreatic adenocarcinoma (PAAD) is one of the most common malignant
tumors of the digestive tract. Pyroptosis is a newly discovered programmed cell death that …

Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …

Abstract Multidrug resistance protein 7 (MRP7), also known as ATP-binding cassette (ABC)
transporter subfamily C10 (ABCC10), is an ABC transporter that was first identified in 2001 …

Recently, FGFR4 has become a hot target for the treatment of cancer owing to its important
role in cellular physiological processes. FGFR4 has been validated to be closely related to …

Tyrosine kinases (TKs) play an important role in pathways that regulate cancer cell
proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been …

The microtubule-targeting agents (MTAs) are well-known chemotherapeutic agents
commonly used for therapy of a broad spectrum of human malignancies, exhibiting epithelial …

Fibroblast growth factors (FGFs) encode a large family of growth factor proteins that activate
several intracellular signaling pathways to control diverse physiological functions. The …

The phenomenon of drug resistance has been a hindrance to therapeutic medicine since
the late 1940s. There is a plethora of factors and mechanisms contributing to progression of …