Artificial biocatalytic linear cascades for preparation of organic molecules
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …
A cascade is defined as the combination of at least two reaction steps in a single reaction …
Transaminase biocatalysis: optimization and application
F Guo, P Berglund - Green Chemistry, 2017 - pubs.rsc.org
Transaminases (TAs) are one of the most promising biocatalysts in organic synthesis for the
preparation of chiral amino compounds. The concise reaction, excellent enantioselectivity …
preparation of chiral amino compounds. The concise reaction, excellent enantioselectivity …
RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades
As the enzyme toolbox for biocatalysis has expanded, so has the potential for the
construction of powerful enzymatic cascades for efficient and selective synthesis of target …
construction of powerful enzymatic cascades for efficient and selective synthesis of target …
Application of ω-Transaminases in the Pharmaceutical Industry
Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have
emerged as an exciting option for their synthesis, offering a potential “green alternative” to …
emerged as an exciting option for their synthesis, offering a potential “green alternative” to …
Enzymatic asymmetric synthesis of chiral amino acids
YP Xue, CH Cao, YG Zheng - Chemical Society Reviews, 2018 - pubs.rsc.org
Chiral amino acids are extensively applied in the pharmaceutical, food, cosmetic,
agricultural, and feedstuff industries. The development of synthetic methodologies for …
agricultural, and feedstuff industries. The development of synthetic methodologies for …
Biocatalytic reductive aminations with NAD (P) H-dependent enzymes: enzyme discovery, engineering and synthetic applications
Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …
reductive amination is one of the most efficient and atom economic methodologies for the …
Multi‐enzymatic cascade reactions: overview and perspectives
E Ricca, B Brucher… - Advanced Synthesis & …, 2011 - Wiley Online Library
Multi‐enzymatic cascade reactions, ie, the combination of several enzymatic transformations
in concurrent one‐pot processes, offer considerable advantages: the demand of time, costs …
in concurrent one‐pot processes, offer considerable advantages: the demand of time, costs …
Biocatalytic reduction reactions from a chemist's perspective
Reductions play a key role in organic synthesis, producing chiral products with new
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …
A growth selection system for the directed evolution of amine-forming or converting enzymes
Fast screening of enzyme variants is crucial for tailoring biocatalysts for the asymmetric
synthesis of non-natural chiral chemicals, such as amines. However, most existing …
synthesis of non-natural chiral chemicals, such as amines. However, most existing …
New generation of biocatalysts for organic synthesis
The use of enzymes as catalysts for the preparation of novel compounds has received
steadily increasing attention over the past few years. High demands are placed on the …
steadily increasing attention over the past few years. High demands are placed on the …