Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics
Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but
does not capture their spatial distribution nor reveal local networks of intercellular …
does not capture their spatial distribution nor reveal local networks of intercellular …
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo
I Chiaradia, MA Lancaster - Nature Neuroscience, 2020 - nature.com
Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …
Conserved cell types with divergent features in human versus mouse cortex
Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA …
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA …
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the
adult mammalian hippocampus,,,,. This process has been linked to learning and memory …
adult mammalian hippocampus,,,,. This process has been linked to learning and memory …
The human cell atlas
A Regev, SA Teichmann, ES Lander, I Amit, C Benoist… - elife, 2017 - elifesciences.org
The recent advent of methods for high-throughput single-cell molecular profiling has
catalyzed a growing sense in the scientific community that the time is ripe to complete the …
catalyzed a growing sense in the scientific community that the time is ripe to complete the …
Organoid single-cell genomic atlas uncovers human-specific features of brain development
The human brain has undergone substantial change since humans diverged from
chimpanzees and the other great apes,. However, the genetic and developmental programs …
chimpanzees and the other great apes,. However, the genetic and developmental programs …
Comprehensive functional genomic resource and integrative model for the human brain
INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …
disorders. However, understanding the underlying molecular mechanisms remains …
Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis
have been challenging because diverse cell types at different stages of maturation and …
have been challenging because diverse cell types at different stages of maturation and …
The next decade in AI: four steps towards robust artificial intelligence
G Marcus - arxiv preprint arxiv:2002.06177, 2020 - arxiv.org
Recent research in artificial intelligence and machine learning has largely emphasized
general-purpose learning and ever-larger training sets and more and more compute. In …
general-purpose learning and ever-larger training sets and more and more compute. In …
Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex
Elucidating the cellular organization of the cerebral cortex is critical for understanding brain
structure and function. Using large-scale single-nucleus RNA sequencing and spatial …
structure and function. Using large-scale single-nucleus RNA sequencing and spatial …