Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading
cause of death. Our previous studies have shown that TNBC progression is greatly …

Macroautophagy is a cellular quality-control process that degrades proteins, protein
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …

Metastasis represents one of the most dangerous issue of cancer progression, characterized
by intricate interactions between invading tumor cells, various proteins, and other cells on …

Autophagy, a lysosomal catabolic process, involves degradation of cellular materials,
protein aggregate, and dysfunctional organelles to maintain cellular homeostasis. Strikingly …

Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …

Autophagy is the key process by which the cell degrades parts of itself within the lysosomes.
It maintains cell survival and homeostasis by removing molecules (particularly proteins) …

Autophagy is a catabolic process that captures cellular waste and degrades them in the
lysosome. The main functions of autophagy are quality control of cytosolic proteins and …

Strategies that induce dysfunction in the endoplasmic reticulum (ER) hold great promise for
anticancer therapy, but remain unsatisfactory due to the compensatory autophagy induction …