Neurodevelopment in Down syndrome: Concordance in humans and models
JA Klein, TF Haydar - Frontiers in cellular neuroscience, 2022 - frontiersin.org
Great strides have been made over the past 30 years in understanding the
neurodevelopmental changes underlying the intellectual disability (ID) in Down syndrome …
neurodevelopmental changes underlying the intellectual disability (ID) in Down syndrome …
Aβ and tau prions feature in the neuropathogenesis of Down syndrome
C Condello, AM Maxwell, E Castillo… - Proceedings of the …, 2022 - National Acad Sciences
Down syndrome (DS) is caused by the triplication of chromosome 21 and is the most
common chromosomal disorder in humans. Those individuals with DS who live beyond age …
common chromosomal disorder in humans. Those individuals with DS who live beyond age …
From neurodevelopment to neurodegeneration: Utilizing human stem cell models to gain insight into Down syndrome
Down syndrome (DS), caused by triplication of chromosome 21, is the most frequent
aneuploidy observed in the human population and represents the most common genetic …
aneuploidy observed in the human population and represents the most common genetic …
[HTML][HTML] Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model
LE Hawley, M Stringer, AJ Deal, A Folz… - Neurobiology of …, 2024 - Elsevier
Aberrant neurodevelopment in Down syndrome (DS)—caused by triplication of human
chromosome 21—is commonly attributed to gene dosage imbalance, linking overexpression …
chromosome 21—is commonly attributed to gene dosage imbalance, linking overexpression …
Ultrasonic vocalization phenotypes in the Ts65Dn and dp (16) 1Yey mouse models of Down syndrome
Down syndrome (DS) is a developmental disorder associated with a high incidence of
challenges in vocal communication. DS can involve medical co-morbidities and structural …
challenges in vocal communication. DS can involve medical co-morbidities and structural …
Hypermetabolism in mice carrying a near-complete human chromosome 21
The consequences of aneuploidy have traditionally been studied in cell and animal models
in which the extrachromosomal DNA is from the same species. Here, we explore a …
in which the extrachromosomal DNA is from the same species. Here, we explore a …
Cortical gradient perturbation in attention deficit hyperactivity disorder correlates with neurotransmitter‐, cell type‐specific and chromosome‐transcriptomic signatures
Aims This study aimed to illuminate the neuropathological landscape of attention deficit
hyperactivity disorder (ADHD) by a multiscale macro–micro‐molecular perspective from in …
hyperactivity disorder (ADHD) by a multiscale macro–micro‐molecular perspective from in …
[HTML][HTML] Develo** Humanized Animal Models with Transplantable Human iPSC-Derived Cells
Establishing reliable and reproducible animal models for disease modelling, drug screening
and the understanding of disease susceptibility and pathogenesis is critical. However …
and the understanding of disease susceptibility and pathogenesis is critical. However …
[HTML][HTML] Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome
Down syndrome (DS) is one of the most common birth defects and the most prevalent
genetic form of intellectual disability. DS arises from trisomy of chromosome 21, but its …
genetic form of intellectual disability. DS arises from trisomy of chromosome 21, but its …
[HTML][HTML] Microcell-mediated chromosome transfer between non-identical human iPSCs
N Uno, H Miyamoto, K Yamazaki, M Egawa… - … Therapy Nucleic Acids, 2024 - cell.com
Microcell-mediated chromosome transfer (MMCT) is anticipated as a unique strategy to
manipulate numbers of chromosomes, including the generation of hyperaneuploidy …
manipulate numbers of chromosomes, including the generation of hyperaneuploidy …