Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but
their individual contributions are obfuscated by the complex in vivo milieu of factor …

Chromatin remodelers act to regulate multiple cellular processes, such as transcription and
DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers …

Chromatin remodellers are specialized multi-protein machines that enable access to
nucleosomal DNA by altering the structure, composition and positioning of nucleosomes. All …

How chromatin remodelers cooperate to organize nucleosomes around the start and end of
genes is not known. We determined the genome-wide binding of remodeler complexes …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

Chromatin is a highly dynamic structure that imparts structural organization to the genome
and regulates the gene expression underneath. The decade long research in deciphering …

Appreciable advances into the process of transcript elongation by RNA polymerase II (RNAP
II) have identified this stage as a dynamic and highly regulated step of the transcription …

Set2-mediated methylation of histone H3 Lys36 (H3K36) is a mark associated with the
coding sequences of actively transcribed genes, but it has a negative role during …