The retinal pigment epithelium in visual function
O Strauss - Physiological reviews, 2005 - journals.physiology.org
Located between vessels of the choriocapillaris and light-sensitive outer segments of the
photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in …
photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in …
An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related …
Age-related macular degeneration (AMD) is a blinding disease that afflicts millions of adults
in the Western world. Although it has been proposed that a threshold event occurs during …
in the Western world. Although it has been proposed that a threshold event occurs during …
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
Age-related macular degeneration is the principal cause of registered legal blindness
among those aged over 65 in the United States, western Europe, Australia, and Japan …
among those aged over 65 in the United States, western Europe, Australia, and Japan …
Age-related macular degeneration
EK de Jong, MJ Geerlings, AI den Hollander - Genetics and genomics of …, 2020 - Elsevier
Age-related macular degeneration (AMD) is a multifactorial disease influenced by a
combination of environmental factors and genetic variants. Genomic studies have been …
combination of environmental factors and genetic variants. Genomic studies have been …
Immunology of age-related macular degeneration
J Ambati, JP Atkinson, BD Gelfand - Nature Reviews Immunology, 2013 - nature.com
Age-related macular degeneration (AMD) is a leading cause of blindness in aged
individuals. Recent advances have highlighted the essential role of immune processes in …
individuals. Recent advances have highlighted the essential role of immune processes in …
Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis …
RF Mullins, SR Russell, DH Anderson… - The FASEB …, 2000 - Wiley Online Library
Age‐related macular degeneration (AMD), a blinding disorder that compromises central
vision, is characterized by the accumulation of extracellular deposits, termed drusen …
vision, is characterized by the accumulation of extracellular deposits, termed drusen …
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited
DH Anderson, MJ Radeke, NB Gallo, EA Chapin… - Progress in retinal and …, 2010 - Elsevier
During the past ten years, dramatic advances have been made in unraveling the biological
bases of age-related macular degeneration (AMD), the most common cause of irreversible …
bases of age-related macular degeneration (AMD), the most common cause of irreversible …
Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts
KM Gehrs, DH Anderson, LV Johnson… - Annals of …, 2006 - Taylor & Francis
Today, the average life expectancy in developed nations is over 80 years and climbing. And
yet, the quality of life during those additional years is often significantly diminished by the …
yet, the quality of life during those additional years is often significantly diminished by the …
Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies
CA Curcio - Investigative ophthalmology & visual science, 2018 - iovs.arvojournals.org
AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …
multidisciplinary research involving human tissues and patients. AMD is a vascular …
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components
Age-related macular degeneration (AMD) is the leading cause of central vision loss
worldwide. Drusen accumulation is the major pathological hallmark common to both dry and …
worldwide. Drusen accumulation is the major pathological hallmark common to both dry and …