With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Estrogens have historically been associated with female reproduction, but work over the last
two decades established that estrogens and their main nuclear receptors (ESR1 and ESR2) …

Therapy for advanced prostate cancer centers on suppressing systemic androgens and
blocking activation of the androgen receptor (AR). Despite anorchid serum androgen levels …

Aromatase is the enzyme that catalyzes the conversion of androgens to estrogens. Initial
studies of its enzymatic activity and function took place in an environment focused on …

Evidence has been accumulating that, in men, some of the biological actions traditionally
attributed to testosterone acting via the androgen receptor may in fact be dependent on its …

Aromatase is expressed in multiple tissues, indicating a crucial role for locally produced
oestrogens in the differentiation, regulation and normal function of several organs and …

Estrogens have significant direct and indirect effects on prostate gland development and
homeostasis and have been long suspected in playing a role in the etiology of prostatic …

Early work on the hormonal basis of prostate cancer focused on the role of androgens, but
more recently estrogens have been implicated as potential agents in the development and …

Background Atrazine is a potent endocrine disruptor that increases aromatase expression in
some human cancer cell lines. The mechanism involves the inhibition of phosphodiesterase …

The proliferation and differentiation of normal prostate epithelial cells depends upon the
action of androgens produced by the testis. Prostate cancers retain the ability to respond to …