Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

Senescent cells drive age-related tissue dysfunction partially through the induction of a
chronic senescence-associated secretory phenotype (SASP). Mitochondria are major …

Mitochondria are cellular factories for energy production, calcium homeostasis and iron
metabolism, but they also have an unequivocal and central role in intrinsic apoptosis …

Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …

Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …

The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

Induction of cell death is inexorably linked with cancer therapy, but this can also initiate
wound-healing processes that have been linked to cancer progression and therapeutic …

According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic …