Guanine-rich DNA sequences can form G-quadruplexes stabilized by stacked G–G–G–G
tetrads in monovalent cation-containing solution. The length and number of individual G …

Over the past decade, nucleic acid chemists have seen the spectacular emergence of
molecules designed to interact efficiently and selectively with a peculiar DNA structure …

Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

Telomeres and telomerase represent, at least in theory, an extremely attractive target for
cancer therapy. The objective of this review is to present the latest view on the mechanism …

G‐quadruplexes are special secondary structures adopted in some guanine‐rich DNA
sequences. As guanine‐rich sequences are present in important regions of the eukaryotic …

The crystal structure of a complex between the bimolecular human telomeric quadruplex d
(TAGGGTTAGGGT) 2 and the experimental anticancer drug BRACO-19, has been …

A series of platinum (II) complexes containing dipyridophenazine (dppz) and C-
deprotonated 2-phenylpyridine (N∧ CH) ligands were prepared and assayed for G …

The G-quadruplex ligands database (G4LDB, http://www. g4ldb. org) provides a unique
collection of reported G-quadruplex ligands to streamline ligand/drug discovery targeting G …

Repeated guanine tracts in human and other genomes can form higher-order four stranded
structures, termed quadruplexes. In the human genome they have particular prevalence in …

Guanine-rich human telomeric DNA can adopt secondary structures known as G-
quadruplexes, which can be targeted by small molecules to achieve anticancer effects. So …