More than meets the eye: The role of microglia in healthy and diseased retina

E Murenu, MJ Gerhardt, M Biel… - Frontiers in …, 2022 - frontiersin.org
Microglia are the main resident immune cells of the nervous system and as such they are
involved in multiple roles ranging from tissue homeostasis to response to insults and circuit …

Application of adaptive optics in ophthalmology

L Liu, Z Wu, M Qi, Y Li, M Zhang, D Liao, P Gao - Photonics, 2022 - mdpi.com
The eye, the photoreceptive organ used to perceive the external environment, is of great
importance to humans. It has been proven that some diseases in humans are accompanied …

[HTML][HTML] Imaging of macrophage-like cells in living human retina using clinical OCT

MV Castanos, DB Zhou, RE Linderman… - … & visual science, 2020 - arvojournals.org
Purpose: To image retinal macrophages at the vitreoretinal interface in the living human
retina using a clinical optical coherence tomography (OCT) device. Methods: Eighteen …

In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury

EB Miller, P Zhang, K Ching… - Proceedings of the …, 2019 - National Acad Sciences
Microglia respond to damage and microenvironmental changes within the central nervous
system by morphologically transforming and migrating to the lesion, but the real-time …

Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization

G Obasanmi, M Uppal, JZ Cui, J **, MJ Ju, J Song, E To… - Angiogenesis, 2024 - Springer
Age-related macular degeneration (AMD) is a common retinal neurodegenerative disease
among the elderly. Neovascular AMD (nAMD), a leading cause of AMD-related blindness …

Microglia activation and inflammation during the death of mammalian photoreceptors

SJ Karlen, EB Miller, ME Burns - Annual review of vision …, 2020 - annualreviews.org
Photoreceptors are highly specialized sensory neurons with unique metabolic and
physiological requirements. These requirements are partially met by Müller glia and cells of …

Temporal speckle-averaging of optical coherence tomography volumes for in-vivo cellular resolution neuronal and vascular retinal imaging

P Zhang, EB Miller, SK Manna, RK Meleppat… - …, 2019 - spiedigitallibrary.org
It has been recently demonstrated that structures corresponding to the cell bodies of highly
transparent cells in the retinal ganglion cell layer could be visualized noninvasively in the …

Imaging the dynamics of individual processes of microglia in the living retina in vivo

A Joseph, D Power, J Schallek - Biomedical Optics Express, 2021 - opg.optica.org
Microglia are an essential population of resident immune cells in the central nervous system
(CNS) and retina. These microscopic cells possess sub-cellular processes that make them …

Sensorless adaptive-optics optical coherence tomographic angiography

A Camino, P Zang, A Athwal, S Ni, Y Jia… - Biomedical Optics …, 2020 - opg.optica.org
Optical coherence tomographic angiography (OCTA) can image the retinal blood flow but
visualization of the capillary caliber is limited by the low lateral resolution. Adaptive optics …

In vivo multi-contrast depth-resolved choroidal imaging of a mouse using polarization-diversity optical coherence tomography

J Song, Y Hu, A Chen, HS Yoo, RJ Zawadzki… - Optics Letters, 2024 - opg.optica.org
The results of depth-resolved multi-contrast in vivo mouse choroidal imaging using a
polarization-diversity optical coherence tomography (PD-OCT) system are presented. A …